Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (49): 9271-9274.doi: 10.3969/j.issn.1673-8225.2011.49.035

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Application progress of bone marrow mesenchymal stem cells in tissue-engineering research

Zhao Da-cheng, Wang Yu-liang, Dang Yue-xiu, Zhao Lin   

  1. Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou  730020, Gansu Province, China
  • Received:2011-06-01 Revised:2011-07-18 Online:2011-12-03 Published:2011-12-03
  • Contact: Wang Yu-liang, Master's supervisor, Chief physician, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730020, Gansu Province, China wyl60918@sina.com
  • About author:Zhao Da-cheng★, Studying for master’s degree, Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730020, Gansu Province, China zhaodacheng09@163.com
  • Supported by:

    the Natural Science Foundation of Gansu Province, No. 2009GS02583*

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Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) play a significant role in tissue engineering as good seed cells.
OBJECTIVE: To descript the experimental status of BMSCs in the bone, cartilage, liver, tendons and heart tissue engineering applications, clarify the momentousness role of BMSCs in tissue engineering.
METHODS: A computer-based online search was conducted in NCBI database and PubMed database for literatures about the application of BMSCs in tissue engineering published from January 2000 to October 2010 with the key words of “Bone marrow mesenchymal stem cells, Mesenchymal stem cells, tissue engineering” in English. Exclusive criteria included repetitive studies and no original research.
RESULTS AND CONCLUSION: According to the included and excluded criterion, a total of 33 references were selected to analysis. BMSCs proliferation activity, had potentiality of multi-directional differentiation, it could differentiated to osteoblasts, chondrocytes, hepatocytes, tendon cells and myocardial cells. Therefore, BMSCs might be favorable seed cell to utilize in tissue engineering, and treated clinical correlated diseases. This article confirmed BMSCs had a highly utilization value in tissue engineering, and was hoped to solve puzzlers problems applied with tissue engineering in the treatment of related diseases.

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