Abstract:

BACKGROUND: Polymer materials play an important role in drug controlled release system. But nano-inorganic materials are studied as a new drug and gene controlled delivery carrier and appears to be very promising, so more considered are paied attention to the design and research of drug controlled release carrier materials.
OBJECTIVE: To summarize the applications and research progress of drug controlled release materials.
METHODS: Database of CNKI and Elsevier SD (1999-01/2011-01) were retrieved to search the related articles about the materials for drug controlled release using the keywords of “polymer, mesoporous materials, inorganic silicon, calcium phosphate, controlled release” in Chinese and English. Finally, 25 articles were included in review analysis.
RESULTS AND CONCLUSION: Drug controlled release carrier materials are widely drawn by their low dosage, long duration and good target effect. But there are still some deficiencies such as the drug inactivation and loss of biological activity after drug loading. The clinical application of drug controlled release carrier materials will be used more widely along with the development of composite carriers for drug delivery and transdermal drug delivery systems.