Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8741-8744.doi: 10.3969/j.issn.1673-8225.2011.47.001

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Choukroun’s platelet-rich fibrin combined with autogenic morselized bone promotes rabbit skull regeneration

Wang De-li1, Kong Xiang-pan2, Luan Hai-rong1, Lu Shan1, Shang Wei-rong3   

  1. 1Mudanjiang Medical College, Mudanjiang  157011, Heilongjiang Province, China
    2Department of Stomatology, Hongqi Hospital, Mudanjiang  157011, Heilongjiang Province, China
    3Social Medical Care Center, Office of Social Enterprise Development, Development Area of Changchun, Changchun  130021, Jilin Province, China
  • Received:2011-04-02 Revised:2011-05-09 Online:2011-11-19 Published:2011-11-19
  • Contact: Shang Wei-rong, Professor, Social Medical Care Center, Office of Social Enterprise Development, Development Area of Changchun, Changchun 130021, Jilin Province, China koujieswr@163.com
  • About author:Wang De-li★, Studying for master’s degree, Lecturer, Mudanjiang Medical College, Mudanjiang 157011, Heilongjiang Province, China
  • Supported by:

    the Scientific Research Project of Heilongjiang Health Bureau, No. 2010-255*; Scientific Research Project of Mudanjiang Medical College, No. 2010-29*

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Abstract:

BACKGROUND: Autogenic morselized bone is an ideal substitute for tissue engineered stent. Choukroun’s platelet-rich fibrin (PRF) can enhance the bone regeneration. Whether the combination of the two materials can achieve a better effect need to be explored.
OBJECTIVE: To investigate the effect of Choukroun’s PRF combined with autogenic morselized bone in repairing skull bone defects.
METHODS: Two standard defects were made by grinded osteotomy on each animal’s skull and then Choukroun’s PRF combined with autogenic morselized bone were used to filled the defect sites on one side as the experimental group and Choukroun’s PRF alone was used on the another side as control group. At postoperatively 4, 6, and 8 weeks, soft X-ray and histological staining were applied.
RESULTS AND CONCLUSION: The new bone area was significantly larger in the experimental group than in the control group as well as bone healing, bone trabacula density and shape, volume and structure of new bone and number of osteoblasts (P < 0.05 or P < 0.01). It is indicated that Choukroun’s PRF combined with autogenic morselized bone can significantly improve the repair of bone defects superior to Choukroun’s PRF alone.

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