Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5781-5784.doi: 10.3969/j.issn.1673-8225.2011.31.019

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Evaluation of donor’s renal function during living-related donor kidney transplantation

Zhao Yu-bo1, Shi Bin-yi2, Fang Jia-li3, Chen Zheng3, Pan Guang-hui3, Chen Jian-bing3, Wang Ke4, Gao Zhen-li4   

  1. 1Department of Urology, Navy General Hospital of Chinese PLA, Beijing 100048, China
    2Organ Transplantation Centre of Chinese PLA, Second Affiliated Hospital of General Hospital of Chinese PLA, Beijing 100091, China
    3Organ Transplantation Centre, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China
    4Department of Urology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, Shandong Province, China
  • Received:2010-12-15 Revised:2011-03-06 Online:2011-07-30 Published:2011-07-30
  • Contact: Shi Bing-yi, Master, Chief physician, Professor, Doctoral supervisor, Organ Transplantation Centre of Chinese PLA, Second Affiliated Hospital of General Hospital of Chinese PLA, Beijing 100091, China shibingyi@medmail. com.cn
  • About author:Zhao Yu-bo☆, Doctor, Attending physician, Department of Urology, Navy General Hospital of Chinese PLA, Beijing 100048, China drzhaoyubo@sina. com

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Abstract:

BACKGROUND: Proper effective evaluation of bilateral renal function before kidney transplantation is of importance for the safety of donors and recipients during living-related donor kidney transplantation.
OBJECTIVE: To investigate the suitable indexes for evaluating living donor’s renal function in living-related donor kidney transplantation.
METHODS: A total of 173 cases of living-related donor kidney transplantation were analyzed retrospectively. The donor grafts were divided into two groups: elderly group (≥ 55 years) and young- and middle-aged group (< 55 years). Before kidney transplantation, there was no significant difference in the indexes which reflect renal function, including serum creatinine, total glomerular filtration rate (GFR), remaining renal GFR, endogenous creatinine clearance rate, and blood urea nitrogen. Change in each index of renal function was compared before and after kidney transplantation.
RESULTS AND CONCLUSION: Compared with before transplantation, serum creatinine and blood urea nitrogen levels were increased while renal total GFR was decreased at 10 days after transplantation (P < 0.01). At 1 month after transplantation, remaining renal total GFR was increased (P = 0.0000), but it increased compared with before transplantation. These findings suggest the renal total GFR can be used as a main index for evaluating the donor’s renal function during living-related donor kidney transplantation, but it would provide more reliable information if combining with serum creatinine and endogenous creatinine clearance rate.

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