Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5751-5755.doi: 10.3969/j.issn.1673-8225.2011.31.012

Previous Articles     Next Articles

Platelet-rich plasma fibrin glue in the early stage for survival rate of autogeneic fat graft

Li Hong-mian1, 2, Liu Da-lie3, Wu Tao4, Zhao Pei-ran 4, Liang Shuang-wu4   

  1. 1Department of Plastic and Aesthetic Surgery, Postdoctoral Research Center, Affiliated Zhongshan Hospital of Sun Yat-Sen University,  Zhongshan  528403, Guangdong Province, China
    2Postdoctoral Research Center, Southern Medical University, Guangzhou  510515, Guangdong Province, China
    3Department of Plastic and Reconstructive Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou  510282, Guangdong Province, China
    4Research Center for Tissue Engineering, Southern Medical University, Guangdong  510515, Guangdong Province, China
  • Received:2011-03-31 Revised:2011-05-11 Online:2011-07-30 Published:2011-07-30
  • Contact: Liu Da-lie, Professor, Chief physician, Doctoral supervisor, Department of Plastic and Reconstructive Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China Liudalie@hotmail.com
  • About author:Li Hong-mian☆, Doctor, Associate chief physician, Master’s supervisor, Department of Plastic and Aesthetic Surgery, Postdoctoral Research Center, Affiliated Zhongshan Hospital of Sun Yat-Sen University, Zhongshan 528403, Guangdong Province, China; Postdoctoral Research Center, Southern Medical University, Guangzhou 510515, Guangdong Province, China binrong2112@163.com
  • Supported by:

    Batch 45 Ph.D. Programs Foundation of Ministry of Education of China, No.20090450910*

PDF

793

Abstract:

BACKGROUND: Autogeneic fat is the ideal filling material in aesthetic and reconstructive surgery. However, the autogeneic fat graft produces serious impact on long-term effect because much fat would be absorbed after transplantation. Accordingly, difficulties in this field are how to increase the survival rate of autogeneic fat graft.
OBJECTIVE: To investigate the effect of platelet-rich plasma (PRP) on the survival rate of autogeneic free grain fat grafts.
METHODS: The fat was harvested from abdominal region of healthy adults and purified. At the same time, venous blood was taken from concurrent patients and PRP was prepared by centrifugation. The grafts were made using fibrin glue combined with PRP according to the physical characteristics of fibrin glue. A subdermal pocket was created in each side of the dorsal midline, the grafts which carried fat particle and PRP fibrin glue were randomly implanted below the deep fascia of the pocket as an experimental group, and simple fat particles were grafted into another pocket as a control group.
RESULTS AND CONCLUSION: At 1 and 3 months after implantation, compared with the control group, angiogenesis surrounding the implanted fat particles was significantly obvious (P < 0.05), the maintenance rate of free fat graft was significantly high (P < 0.05), and fibrous proliferation and steatonecrosis rate was significantly low (P < 0.05) in the experimental group. Results showed that PRP fibrin glue can increase angiogenesis and weight maintenance rate of the free fat grafts in the early stage, and at the same time, it can also decrease the fibrous proliferation and steatonecrosis rate of the free fat grafts.

CLC Number: