Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (31): 5707-5712.doi: 10.3969/j.issn.1673-8225.2011.31.002

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Analysis of liver function test and screening of early warning indicators for biliary cast group after orthotopic liver transplantation

Yang Yu-long1, Liu Zhen-wen2, Lin Mei-ju1, Zhang Hong-wei1, Shi Li-jun1   

  1. 1Department of Biliary Minimally Invasive Surgery, Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
    2Organ Transplantation Center, the 302 Hospital of Chinese PLA, Beijing 100039, China
  • Received:2011-02-17 Revised:2011-06-23 Online:2011-07-30 Published:2011-07-30
  • About author:Yang Yu-long, Professor, Chief physician, Department of Biliary Minimally Invasive Surgery, Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China YYL516@126.com
  • Supported by:

    Science and Technology Bureau Plan Program of Dalian City, No. 2010E15SF178*

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Abstract:

BACKGROUND: When biliary cast syndrome in liver transplantation is identified, the transplanted liver has been injured to different extents because of obstruction of biliary tract and repeated infection, therefore, it is extremely important to detect biliary cast syndrome.
OBJECTIVE: To detect the liver function of patients who underwent orthotopic liver transplantation and exhibited biliary cast complications and to screen the warning indicators for early diagnosis of biliary casts.
METHODS: We retrospectively analyzed the liver function indices of 25 patients with biliary tract complications after liver transplantation, which have been confirmed by endoscopic or radiographic cholangiography. The 25 patients were assigned to four groups according to the syndromes: biliary cast (n =7), biliary duct anastomotic stricture (n = 5), biliary cast + anastomotic biliary stricture (n = 13) and normal biliary duct (n = 18).
RESULTS AND CONCLUSION: At 1 week after liver transplantation, there was no significant difference in liver function indices between normal biliary duct and other groups (P > 0.05). At 1 months after liver transplantation, serumγ-glutamyl transpeptidase was significantly higher in the biliary cast group, biliary cast + anastomotic biliary stricture group than in the normal biliary duct group (P< 0.01), and it was significantly lower in the biliary duct anastomotic stricture group than in the biliary cast group (P < 0.05). The results showed that biliary cast is the potential complication of orthotopic liver transplantation; serumγ-glutamyl transpeptidase can be used as an warning indicator of biliary cast group after orthotopic liver transplantation and it is also an important reference indicator for identification of jaundice causes following surgery and an indication for choledochoscopy and surgical treatment.

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