Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (20): 3737-3740.doi: 10.3969/j.issn.1673-8225.2011.20.030

Previous Articles     Next Articles

Expression of interleukin-8 in periodontal tissue during experimental tooth movement in rats

Pan Xu, Mi Cong-bo, Liu Hong, Qian Ya-jing, Nie Jing   

  1. Department of Orthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uighur Autonomous Region, China
  • Received:2010-11-08 Revised:2010-12-08 Online:2011-05-14 Published:2011-05-14
  • Contact: Mi Cong-bo, Chief physician, Master’s supervisor, Department of Orthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China mi670105@sina.com
  • About author:Pan Xu, Department of Orthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uighur Autonomous Region, China panxu423@hotmail. com
  • Supported by:

    the Youth Foundation of Science and Technology Research of First Affiliated Hospital of Xinjiang Medical University*, No. 2009-QN-16*

PDF

383

Abstract:

BACKGROUND: Interleukin-8 (IL-8) as a bone remodeling associated with inflammatory cytokines, involved in periodontal tissue remodeling, and promote the absorption of alveolar bone, which is one marker of bone resorption.
OBJECTIVE: To observe the effects of orthodontic force on (IL-8) expression during periodontal tissue remodeling.
METHODS: The orthodontic devices were placed in maxillary first molars and maxillary incisors side of 10-week-old male SD rats, and impose 0.49 N orthodontic force. The specimen was harvested at 1, 3, 5, 7 and 14 days after operation and the surface density of IL-8 positive cells in periodontal tissues were determined by morphology analysis and immunohistochemical staining.
RESULTS AND CONCLUSION: The expression of IL-8 was observed at a low level in the control group. IL-8 expression increased after tooth movement and reached a peak at 5 days, after that, it gradually declined. Orthodontic force can cause local inflammation and periodontal tissue IL-8 release. IL-8 release may be an early inflammatory reaction in periodontal tissue and alveolar bone remodeling of the trigger factor at early stage of orthodontic tooth movement.

CLC Number: