Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3577-3580.doi: 10.3969/j.issn.1673-8225.2011.19.038

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Current understanding into the biological characteristics of mesenchymal stem cells

Lin Zhi-xiang1, Xu Hao2   

  1. 1Anhui Medical University, Hefei  230032, Anhui Province, China
    2First Department of Orthopedics, Fuzhou General Hospital of Nanjing Military Area Command, Fuzhou  350025, Fujian Province, China
  • Received:2011-02-26 Revised:2011-04-06 Online:2011-05-07 Published:2011-05-07
  • Contact: Xu Hao, Professor, Master’s supervisor, First Department of Orthopedics, Fuzhou General Hospital of Nanjing Military Area Command, Fuzhou 350025, Fujian Province, China
  • About author:Lin Zhi-xiang★, Studying for master’s degree, Anhui Medical University, Hefei 230032, Anhui Province, China linzhx@yahoo.cn

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Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) have been widely used in clinical studies and treatment. Numerous studies have reported beneficial effects of MSCs in tissue repairing as well as immunomodulatory function reported recently. But it is unclear that how MSCs exert the effects.
OBJECTIVE: To discuss the immunomodulatory mechanism of MSCs.
METHODS: The PubMed database was researched using the computer for articles published from 2000 to 2010 using key words “mesenchymal stem cells, tissue repairing, homing, immunomodulatory” in English. Inclusion criteria: articles relevant to the machnism of MSCs to exert homing and immunomodulatory effects after tissue injury. Exclusion criteria: repetitive studies or irrelevant articles.
RESULTS AND CONCLUSION: Totally 50 articles were included in the result analysis. MSCs effects on the repair of tissue injury have been confirmed, and the immune function of MSCs has been reported recently. The mechanism is pleiotropic and redundant, mediated by multiple factors glands - receptor reaction and related immune cells which are involved in this process. The mechanisms of MSCs are still unclear, further researches are needed to confirm and improve, so as to further promote clinical research and treatment.

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