Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (19): 3573-3576.doi: 10.3969/j.issn.1673-8225.2011.19.037

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Migration mechanism of bone marrow mesenchymal stem cells

Xu Shi-hong1, Xie Xing-wen2   

  1. 1Gansu College of Traditional Chinese Medicine, Lanzhou  730000, Gansu Province, China
    2Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou  730020, Gansu Province, China
  • Received:2010-11-23 Revised:2011-03-12 Online:2011-05-07 Published:2011-05-07
  • Contact: Xie Xing-wen, Doctor, Associate chief physician, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730020, Gansu Province, China
  • About author:Xu Shi-hong★, Studying for master’s degree, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China xushihong2015@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81060299*

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Abstract:

BACKGROUND: Based on the multiple differentiation potential, bone marrow mesenchymal stem cells (BMSCs) migrating to the injury site greatly promote patient’s rehabilitation.
OBJECTIVE: To investigate the mechanism of cytokines and inflammatory factors to promote the migration of BMSCs based on analysis of related literature.
METHODS: The first author retrieved China National knowledge Infrastructure and PubMed datebases for concering articles .The key words were “BMSCs, chemotactic factor, migration” in Chinese and English. A total of 68 articles were retrieved primarily by computer, and 23 articles were finally included for review according to inclusion criteria. 
RESULTS AND CONCLUSION: BMSCs have a strong differentiation potential and play a huge assistance role in the clinical treatment. At the same time, because BMSCs are easy and simple to harvest and culture in vitro, studies concerning the proliferation, differentiation and migration of BMSCs are hot points. The intervention function of related cell factors urges BMSCs to strength migration.

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