Abstract:

BACKGROUND: Due to the use of immunosuppressants and broad-spectrum antibiotic, the pathogenic bacteria of sepsis is diverse and complex, accompanying with severe illness and high death rate. Therefore, to enforce clinical etiology characteristics understanding of sepsis after renal transplantation and to perform appropriate treatment as soon as possibly are the key to improve infection cure rate.
OBJECTIVE: To analyze the clinical etiology characteristics and therapy of sepsis following renal transplantation.
METHODS: The clinical data of 7 cases of sepsis in 376 patients following renal transplantation were collected from the Department of Nephrology, the First people’s Hospital of Foshan from June 2007 to June 2010. Predisposing factor, etiology characteristics, clinical manifestation and treatment of sepsis were retrospectively analyzed, respectively.
RESULTS AND CONCLUSION: There were 7 cases of shivering and fever (T38.5-40.2 ℃), 4 cases of fantod and breathlessness, and 4 cases of urinary irritation symptoms; 4 cases of blood pressure less than 90/60 mm Hg (1 mm Hg=0.133 kPa) with increased serum creatinine, 4 cases of Escherichia, 1 case of Staphylococcus epidermidis, 1 case of Blastomyces albicans, 1 case of Penicillium marneffi; 5 cases of bacterial infection was community infection, 2 cases of fungous infection was hospital oneset of infection; 4 cases suffered from Escherichia combined with urinary tract infection, and 4 cases suffered from hypotension shock and acute renal failure. Six sepsis patients were cured and one died after giving anti-infective therapy, reducing the dosage of immunosuppressant and symptomatic treatment. Early diagnosis, drug combination, and reducing the dosage of immunosuppressant are the key to improving cure rate against infection.