Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (18): 3371-3375.doi: 10.3969/j.issn.1673-8225.2011.18.035

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Apoptosis and ischemia-reperfusion injury following liver transplantation

Wu Qin-rong, Shi Jun, Wang Yong-gang   

  1. Jiangxi Provincial People’s Hospital, Nanchang  330006, Jiangxi Province, China
  • Received:2010-11-16 Revised:2011-03-18 Online:2011-04-30 Published:2011-04-30
  • Contact: Shi Jun, Doctor, Professor, Master’s supervisor, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China shijun6207@163.com
  • About author:Wu Qin-rong★, Studying for master’s degree, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China Wuqinrong1314@sina.com

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Abstract:

BACKGROUND: Liver transplantation has become an effect means for end-stage liver disease. Hepatic ischemia-reperfusion injury is an important factor to influence the effects of liver transplantation. Cell apoptosis is one of important mechanisms for transplanted liver ischemia reperfusion injury
OBJECTIVE: To provide references for the clinical application of anti-apoptosis treatment in relieving organ ischemia-reperfusion injury based on recent studies about apoptosis and transplanted liver ischemia-reperfusion injury.
METHODS: The databases of PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and CNIKI (http://dlib.cnki.net/kns50/) were retrieved by the first author with key words of “apoptosis, organ transplantation, ischemia-reperfusion injury” in both Chinese and English from 1990 to 2010. The repetitive studies were excluded. Totally 339 articles were gotten by computers according to criteria, 39 articles of which were included in the final analysis.
RESULTS AND CONCLUSION: There is close relationship between the apoptosis and liver ischemia-reperfusion injury. And inhibiting cell apoptosis can effectively reduce the liver ischemia-reperfusion injury, which will play an important role for the graft survival.

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