Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (18): 3337-3340.doi: 10.3969/j.issn.1673-8225.2011.18.026

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Changes in serum soluble Fas and soluble Fas ligand of renal graft recipients in early period post-transplant as a predictor of acute renal allograft rejection

Song Jie, Li Hui, Zhang Xiao-dong, Li Ying   

  1. Department of Nephrology, Affiliated Hospital, Medical College of CAPF, Tianjin  300162, China
  • Received:2010-12-30 Revised:2011-03-07 Online:2011-04-30 Published:2011-04-30
  • Contact: Zhang Xiao-dong, Master, Attending physician, Department of Nephrology, Affiliated Hospital, Medical College of CAPF, Tianjin 300162, China
  • About author:Song Jie★, Master, Attending physician, Department of Nephrology, Affiliated Hospital, Medical College of CAPF, Tianjin 300162, China songjie-7808@163.com

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Abstract:

BACKGROUND: Apoptosis of target cells plays a crucial effect on acute rejection after organ transplantation. Fas/Fas ligand (FasL) system is considered as one of action pathways of acute rejection after organ transplantation.
OBJECTIVE: To study the serum soluble Fas and soluble FasL levels of renal graft recipients in early post-transplant period and their application as a predictor of acute renal allograft rejection.
METHODS: The sequential monitoring of serum soluble Fas and soluble FasL levels in 80 patients was conducted by ELISA technique before and after renal transplantation and the relationship between sFas/sFasL with acute renal allograft rejection were analyzed.
RESULTS AND CONCLUSION: The levels of serum soluble Fas and soluble FasL in the patients for renal transplantation were significantly higher than that in control before operation (P < 0.05). The levels of serum soluble Fas and soluble FasL in acute rejection group at same time were significantly higher than that in normal group after operation (P < 0.05), and compared with that in CsA-induced nephrotoxicity group, there was no significant difference. The sequential monitoring of serum soluble Fas and soluble FasL in renal allograft recipients may be of a useful value to make early and differential diagnosis of acute renal rejection．

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