Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2817-2820.doi: 10.3969/j.issn.1673-8225.2011.15.038

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Gene alternative splicing related to stress regulation

Fu Ya1, 2, 3, Zhang Yao-yao1, 2, Sun Jiao-Xia1, 2, Xiang Yan1, 2, Wang Yuan-liang1, 2   

  1. 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, 2Research Center of Bioinspired Materials Science and Engineering, Bioengineering College, Chongqing University, Chongqing  400044, China; 3Department of Biology, Chongqing University of Science and Technology, Chongqing  401331, China
  • Received:2010-12-11 Revised:2011-01-18 Online:2011-04-09 Published:2013-11-06
  • Contact: Wang Yuan-liang, Doctor, Professor, 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, 2Research Center of Bioinspired Materials Science and Engineering, Bioengineering College, Chongqing University, Chongqing 400044, China bio730@cqu.edu.cn
  • About author:Fu Ya☆, Studying for doctorate, Associate professor, 1Key Laboratory of Biorheological Science and Technology, Ministry of Education, 2Research Center of Bioinspired Materials Science and Engineering, Bioengineering College, Chongqing University, Chongqing 400044, China; Department of Biology, Chongqing University of Science and Technology, Chongqing 401331, China cqfuya@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30870609*, 51043004*; Natural Science Foundation of Chongqing, No. CSTC2009BB4382*; Foundation of Chongqing Municipal Education Commission, No. Kj091415*; the Science and Technology Plan of Jiulongpo Area, No. 090109*

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Abstract:

BACKGROUND: The proper mechanical environment is not only the important factors for organism normal growth and development, structure reestablishment and function maintenance, but also is one of the key factors for functional recovery of injured tissue. The regulation of gene expression by stress does not only reflect the switch or regulation of gene expression, but also is related to alternative splicing after transcription.
OBJECTIVE: The introduction of a new stress regulation by alternative splicing combined with growth factor binding, and to predict the presumable regulatory mechanism.
METHODS: PubMed database (1964 to 2010) and CNKI database (2000 to 2009) were searched for relative review articles and research reports for aspects of signal transduction and genetic alternative splicing, the linkages between the two and possible regulatory mechanisms were analyzed.
RESULTS AND CONCLUSION: Stress stimulation could lead to alternative splicing of insulin like growth factor-1 genes in muscle cells and bone cells, which would produce a new stress-sensitive growth factor mechano-growth factor and reveal a new regulation by stress. The mechanism of regulation is not clear, which may be related to the stress caused by the location of splicing bodies (the displacing movement) and the change of the location and spatial structure (deformation) of splicing enzymes (such as RNP enzyme).

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