Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5281-5284.doi: 10.3969/j.issn.1673-8225.2010.28.036

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Correlation between satellite cells and muscle hypertrophy as well as exercise regulation of myogenic factor 

Wang Jin-yue1, Wang Xiao-hong2, Chen Min-sheng3, Yang Hai-dong4   

  1. 1 Physical Education College, Foshan University, Foshan 528000, Guangdong Province, China; 2 Physical Education College, Northeast Normal University, Changchun  130026, Jilin Province, China; 3 Physical Education College, Shenzhen University, Shenzhen 518060, Guangdong Province, China; 4 Physical Education College, Northeast University, Shenyang 110004, Liaoning Province, China
  • Online:2010-07-09 Published:2010-07-09
  • About author:Wang Jin-yue☆, Doctor, Lecturer, Physical Education College, Foshan University, Foshan 528000, Guangdong Province, China wjytnt@tom.com
  • Supported by:

    the Science and Technology Guidance plan of Jilin Province, No.2010D715*; Subjects of Physical Education Bureau of Jilin Province, No.07B04*, 09B12*, 09B15*

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Abstract:

BACKGROUND: Satellite cells, which proliferate, differentiate and fuse to increase the quantities of nucleuses and myofibers, and then change the function or morphology of skeletal muscle, are the material of myogenesis. Whether muscle hypertrophy might be independent on satellite cells or not is still controversial. Myogenic factors (MRFs) are key factors of myogenesis. However, characteristics and difference among them remain unclear.
OBJECTIVE: To summarize and investigate the effect of satellite cells or MRFs on myogenesis, muscle hypertrophy and musde training.
METHODS: A computer-based online search was conducted in CNKI and Medline databases with the key words of “skeletal muscle, hypertrophy, exercise, myogenesis, satellite cell, MRF” in both Chinese and English from 2000 to 2010. The relation between satellite cells and muscle hypertrophy, funtion and exercise-regulation of MRFs was summarized; while, regulatory mechanism and muscle remolding were investigated.
RESULTS AND CONCLUSION: A total of 177 articles were retrieved. According to inclusion and exclusion criteria, 30 articles were included in the final analysis. The results demonstrated that myogenesis was a basis of muscle hypertrophy, and satellite cells played a key role in myogenesis. However, satellite cells did not participate in early phase of muscle hypertrophy, thus DNA was not a good index to determine changes of satellite cells. MRFs were core factors to cause myogenesis. At present, function and motor regulation of MRFs still need to be further studied.

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