Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (11): 1730-1736.doi: 10.12307/2024.220

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Digital characteristics of brainstem morphology and age-related development in young children

Liu Yanan1, Wang Xing2, 3, Li Kun2, 3, Sun Ruifen4, Ma Xueying5, Zhao Lei5, Liu Yuhang1, Yang Yang1, Hao Yunteng1, Li Ziyu1, Zhang Shaojie2, 3, Li Zhijun2, 3   

  1. 1Graduate School of Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; 2Department of Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; 3Center for Digital Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China; 4Department of Imaging, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China; 5Department of Imaging, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Received:2022-11-30 Accepted:2023-03-09 Online:2024-04-18 Published:2023-07-27
  • Contact: Li Zhijun, Professor, Doctoral supervisor, Department of Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Center for Digital Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China Zhang Shaojie, Professor, Master’s supervisor, Department of Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Center for Digital Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China
  • About author:Liu Yanan, Master candidate, Graduate School of Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China Wang Xing, MD, Associate professor, Department of Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Center for Digital Medicine, Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia Autonomous Region, China
  • Supported by:
    National Natural Science Foundation of China, No. 81860383 (to LZJ), 81860382 (to WX); Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2020LH08021 (to LZJ), 2020MS03061 (to WX), 2019MS08017 (to ZSJ), 2022QN03002 (to LK); the Support Program for Young Scientists and Technologists in Higher Education Institutions of Inner Mongolia Autonomous Region, No. NJYT22009 (to WX); Science and Technology Program of Inner Mongolia Autonomous Region, No. 2019GG158 (to WX); Key Project of Scientific Research of Inner Mongolia Medical University, No. YKD2021ZD011 (to WX); Medical and Health Science and Technology Program of Inner Mongolia Autonomous Region Health and Health Commission, No. 202201217 (to WX); Youth Fund Project of Inner Mongolia Medical University, No. YKD2020QNCX055 (to LK)

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Abstract: BACKGROUND: Previous brain studies have mostly focused on adults and fetuses, and the developmental characteristics of young children's brainstems have rarely been studied.
OBJECTIVE: To observe the brainstem development characteristics of healthy young children and to explore the age-related differences and their correlation with sex.
METHODS: From January 2019 to April 2022, a retrospective study of 3.0T MRI images of 174 children aged 2 to 6 years in the Affiliated Hospital of Inner Mongolia Medical University was conducted, and the median sagittal diameter, area and angle of the brainstem (including midbrain, pons and medulla oblongata) were measured.
RESULTS AND CONCLUSION: There is an age-related increase in the anterior and posterior diameters of the midbrain, pons and medulla oblongata in the 2-5 years old group as well as in the longitudinal diameter and area of the midbrain, pons and medulla oblongata in the 2-6 years old group. Except for the longitudinal diameter of the medulla oblongata, all others show a positive correlation with age (r > 0, P < 0.05). In the 2-3 years old group and 4-5 years old group, the children are in the rapid growth and development stage, and these two age groups can be used as the key observation indicators for the development of young children. The anterior-posterior diameter, longitudinal diameter, area of the pons and total brainstem area are strongly correlated with age, which can be used as the key observation indicators for the brainstem development in young children.

Key words: brainstem, radial line, area, intersection angle, MRI, morphological developmental feature, young children

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