Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (34): 5537-5543.doi: 10.12307/2021.252

Previous Articles     Next Articles

Research and clinical application of calcium phosphate cement modification

Liu Rixu, Lü Wenbo, Gao Wenshan   

  1. First Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
  • Received:2020-07-23 Revised:2020-07-25 Accepted:2020-08-19 Online:2021-12-08 Published:2021-07-28
  • Contact: Gao Wenshan, Chief physician, Professor, Master’s supervisor, First Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
  • About author:Liu Rixu, Master candidate, First Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China

Abstract: BACKGROUND: Calcium phosphate bone cement has good self-fixation, easy formability, good biocompatibility, and bone conductivity, and is an excellent bone graft material. However, calcium phosphate cement still has the problems of poor mechanical strength, slow degradation rate, and low biocompatibility.
OBJECTIVE: To explore the research and clinical application of calcium phosphate cement modification.
METHODS: Web of Science, PubMed, Wanfang, and CNKI were searched using “calcium phosphate bone cement, modification” as English and Chinese keywords to search the relevant articles published from 2014 to 2020. Irrelevant and duplicate articles were excluded, and 72 articles that met the standard were finally included.
RESULTS AND CONCLUSION: To date, calcium phosphate cement and biologically active substances, metal and non-metal elements, organic matter, and stem cells have been mixed in different ways to improve their mechanical strength, biocompatibility, and promote bone regeneration. Although some properties of bone cement can be improved by adding different materials, it is still in the experimental stage, and the calcium phosphate cement is not ideal. In the clinical application of calcium phosphate cement, it has a better effect on repairing defects of fractures, osteomyelitis, and bone tumors than traditional treatment methods. However, complications such as slow growth rate of new bone and slow degradation of bone cement, severe infection at the injection site, and collapse of the filler occurred during the application.

Key words: bone, material, calcium phosphate cement, modification, clinical application, mechanical properties, bone regeneration, biologically active substance, review

CLC Number: