Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (31): 5065-5071.doi: 10.12307/2021.152

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Characteristics and effects of exosomes from different cell sources in cardioprotection

Pu Rui, Chen Ziyang, Yuan Lingyan   

  1. Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China
  • Received:2020-10-13 Revised:2020-10-14 Accepted:2020-11-19 Online:2021-11-08 Published:2021-04-25
  • Contact: Yuan Lingyan, MD, Professor, Doctoral supervisor, Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China
  • About author:Pu Rui, Master candidate, Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China
  • Supported by:
    the National Natural Science Foundation of China, No. 31371196 (to YLY)

Abstract: BACKGROUND: More and more studies have shown that exosomes have become a new direction in the diagnosis and treatment of various diseases. Exosomes play an important role in cardioprotection, but their specific mechanisms have not been fully elucidated. 
OBJECTIVE: To summarize the diagnostic role of exosomes in cardiovascular diseases, and summarize the research on cardioprotection of exosomes from different cell sources, in order to provide a theoretical reference for better prevention and treatment of cardiovascular diseases.
METHODS: The key words were “exosomes, cardioprotection, cardiomyocytes, endothelial cells, cardiac fibroblasts, cardiac progenitor cells, mesenchymal stem cells” in Chinese and English. The articles on various cell-derived exosomes and cardioprotection published from 1981 to 2020 were searched. According to the inclusion and exclusion criteria, 72 articles were finally included for summary and induction.

RESULTS AND CONCLUSION: (1) Exosomes are closely related to the occurrence and development of cardiovascular diseases, and play a beneficial effect in the screening, diagnosis and prognosis of a variety of cardiovascular diseases, so exosomes can be used as potential biomarkers for the diagnosis of cardiovascular diseases. (2) Cardiomyocytes, endothelial cells, cardiac fibroblasts, cardiac progenitor cells, and mesenchymal stem cells derived exosomes mediated miRNA and related proteins play an important role in cardioprotection.

Key words: exosomes, cardioprotection, cardiomyocytes, endothelial cells, cardiac fibroblasts, cardiac progenitor cells, mesenchymal stem cells, review

CLC Number: