Research hotspot of seed cell selection in cartilage tissue engineering

doi:10.12307/2021.151

Abstract

Abstract: BACKGROUND: The repair of cartilage defects such as ears, noses, throats, trachea and joints has always been one of the difficulties faced by clinical treatment. The emergence of cartilage tissue engineering has become a popular development direction for cartilage repair, in which seed cells are used to construct tissue engineered cartilage key.
OBJECTIVE: This article intends to review the characteristics of various types of seed cells, their application in cartilage tissue engineering, and existing problems, and to bring new ideas to clinical transformation.
METHODS: The first author searched the relevant articles of CNKI, Wanfang, PubMed, Scopus and Web of Science databases, using “seed cells; tissue engineering; chondrocytes; stem cells; co-cultivation” as the Chinese and English search terms. Finally, 70 articles that met the criteria were selected for review.

RESULTS AND CONCLUSION: (1) Current experimental research on cartilage tissue engineering has achieved a lot of results, but the problem of selecting seed cells is still a big problem. Chondrocytes, various types of mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells have different degrees of advantages, but also face different challenges. (2) The discovery, development and application of various seed cells have promoted the progress of cartilage tissue engineering. Among them, the method of co-culture of chondrocytes and stem cells is currently a popular and promising seed choice for research.

Key words: seed cells, cartilage tissue engineering, chondrocytes, mesenchymal stem cells, embryonic stem cells, co-culture

CLC Number:

Liu Xiaogang, Li Tian, Zhang Duo. Research hotspot of seed cell selection in cartilage tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5059-5064.

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