Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (31): 5053-5058.doi: 10.12307/2021.150

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Mesenchymal stem cells in the treatment of cartilage damage in osteoarthritis: role, application, and problem

Wang Xinwei, Zhao Yingjie, Chang Yan, Wei Wei   

  1. Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China 
  • Received:2020-05-08 Revised:2020-05-13 Accepted:2020-09-05 Online:2021-11-08 Published:2021-04-25
  • Contact: Chang Yan, MD, Professor, Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China
  • About author:Wang Xinwei, Master candidate, Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 81573443, 81673444 (to CY); the Anhui Province Natural Science Fund (Outstanding Youth), No. 170808J10 (to CY); the Key Projects of Outstanding Young Talent Support Program in Colleges and Universities in 2016, No. gxyqZD2016043 (to CY)

Abstract: BACKGROUND: Mesenchymal stem cells have a wide range of sources and are easy to be isolated and cultured. It also has the functions of multidirectional differentiation, tissue repair, anti-inflammatory and immune regulation, which provides a new approach for the treatment of articular cartilage injury.
OBJECTIVE: To review the application and research of mesenchymal stem cells in the treatment of osteoarthritis cartilage damage.
METHODS: Using “osteoarthritis, cartilage damage, mesenchymal stem cell, treatment” as the English and Chinese keywords, the first author retrieved the included in PubMed and CNKI databases from 2000 to 2020. After excluding articles that were not relevant and repetitive for the purpose of the article, fifty articles were included for review in the end.  
RESULTS AND CONCLUSION: (1) Tissue engineering methods combined the multi-differentiation function of mesenchymal stem cells with the characteristics of bioscaffold materials can better promote the repair of damaged cartilage, and has made many achievements in basic research and clinical research. (2) Joint injection of mesenchymal stem cells with the solvent can exert the therapeutic effect and expand the advantages of mesenchymal stem cells. (3) Mesenchymal stem cell exosome for the therapy of osteoarthritis cartilage damage is still in the basic stage, which will become the developmental trend of osteoarthritis cartilage damage treatment.

Key words: stem cells, mesenchymal stem cells, osteoarthritis, cartilage injury, treatment, tissue engineering, review

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