Possibility of in utero stem cell therapy for multiple fetal genetic diseases

doi:10.12307/2021.147

Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (31): 5034-5039.doi: 10.12307/2021.147

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Possibility of in utero stem cell therapy for multiple fetal genetic diseases

Jie Qiuling1, 2, 3, 4, Sun Fei1, 2, 3, 4

Received:2020-06-18 Revised:2020-06-24 Accepted:2020-08-13 Online:2021-11-08 Published:2021-04-25
Contact: Sun Fei, MD, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China; Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Department of Reproductive Medicine, Hainan Provincial Clinical Research Center for Thalassemia, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 570102, Hainan Province, China; Haikou Key Laboratory for Preservation of Human Genetic Resource, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China
About author:Jie Qiuling, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China; Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, Department of Reproductive Medicine, Hainan Provincial Clinical Research Center for Thalassemia, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 570102, Hainan Province, China; Haikou Key Laboratory for Preservation of Human Genetic Resource, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, Hainan Province, China
Supported by:
the General Project of Basic and Applied Basic Research Fund of Guangdong Province, No. 2019A1515010019 (to SF); Presidential Foundation of Nanfang Hospital, Southern Medical University, No. 2018Z014 (to SF), No. 2017C001 (to SF); the National Natural Science Foundation of China, No. 81660433 (to SF)

Abstract

Abstract: BACKGROUND: The development of prenatal diagnosis and screening technology has made prenatal treatment possible. For a variety of fetal genetic diseases, in utero stem cell therapy has significant advantages.
OBJECTIVE: To analyze the feasibility of in utero stem cell therapy in prenatal fetal diseases through the existing experimental research and clinical data.
METHODS: Databases of PubMed, Wanfang and CNKI were searched for the articles published from the inception to June 16, 2020. The keywords were “in utero stem cells, fetal” in English and Chinese, respectively.
RESULTS AND CONCLUSION: With the development of prenatal diagnosis screening technology and stem cell therapy technology, in utero stem cell therapy has a significant advantage in the treatment of various fetal genetic diseases. The physiological characteristics of fetal development also provide conditions for in utero stem cell transplantation. The preclinical animal experiment research has laid the foundation for the clinical application of in utero stem cell transplantation treatment from the aspects of chimera implantation level and immune tolerance. In recent years, the development of prenatal diagnosis and screening technology, along with high-throughput molecular testing and minimally invasive surgery, can detect a variety of fetal diseases in early pregnancy, and also makes prenatal intrauterine treatment possible.

Key words: in utero stem cell therapy, immunity, hereditary diseases, severe combined immunodeficiency, hematopoietic stem cell therapy, mesenchymal stem cell therapy, amniotic fluid stem cell, therapy, review

CLC Number:

Jie Qiuling, Sun Fei. Possibility of in utero stem cell therapy for multiple fetal genetic diseases[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5034-5039.

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Possibility of in utero stem cell therapy for multiple fetal genetic diseases

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