Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (31): 5000-5011.doi: 10.12307/2021.143
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Li Qiujiang1, Fang Xiaomin1, 2, Wang Yinbin1, 2, Hu Xuehua2, Cai Lijun1, 2
Received:
2020-07-13
Revised:
2020-07-14
Accepted:
2020-08-19
Online:
2021-11-08
Published:
2021-04-25
Contact:
Cai Lijun, Associate professor, Chief physician, Master’s supervisor, Third Clinical Medical College of Ningxia Medical University (People’s Hospital of Ningxia Hui Autonomous Region), Yinchuan 750002, Ningxia Hui Autonomous Region, China; The First Clinical Medical College of Northwest University for Nationalities (People’s Hospital of Ningxia Hui Autonomous Region), Lanzhou 730000, Gansu Province, China
About author:
Li Qiujiang, Master candidate, Third Clinical Medical College of Ningxia Medical University (People’s Hospital of Ningxia Hui Autonomous Region), Yinchuan 750002, Ningxia Hui Autonomous Region, China
Supported by:
CLC Number:
Li Qiujiang, Fang Xiaomin, Wang Yinbin, Hu Xuehua, Cai Lijun. Current states and tendency of stem cells in the treatment of intervertebral disc degeneration: bibliometric analysis[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5000-5011.
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2.5 干细胞在椎间盘退变治疗研究中的学科分布 从总发文量上看,在干细胞治疗椎间盘退变性疾病研究方向主要为工程学(205篇),其次依次为细胞生物学(188篇)、骨科(174篇)、材料科学(133篇) 和临床神经病学(111篇)等方向,基本上偏向于基础研究方向,而相对外科手术学(27篇)方向的发文量甚少。从中心性指标来看,细胞生物学以中介中心性0.6系数值位列首位,其次依次为分子生物化学(0.36)、生物物理学(0.34)、材料科学(0.33) 和实验研究(0.22)等。同样从可视化图谱可见干细胞治疗椎间盘退变性疾病领域的研究方向主要以细胞生物学、组织工程学、骨科和材料科学为中心,相互交叉,相互联系,见图8-10。"
2.6 干细胞在椎间盘退变治疗研究中基金分布 文章通过对干细胞治疗椎间盘退变研究领域的基金支持情况进行分析,共列举了前20位基金项目,以中国国家自然科学基金项目支持的文献最多,共支持了149篇文献;项目“UNITED STATES DEPARTMENT OF HEALTH HUMAN SERVICES”和“NATIONAL INSTITUTES OF HEALTH NIH USA”均以72篇文献位列第2名;其中浙江省自然科学基金以支持15篇文献位列6名;此外“AO FOUNDATION”“AOSPINE”和“AO SPINE INTERNATIONAL”分别支持了16,11,9篇文献,均位于Top 20名次内, 见图11。"
2.7 干细胞在椎间盘退变治疗研究中作者分析 从作者发文量方面看,以日本学者DAISUKE SAKAI学者28篇发文量位居首位,其次依次为爱尔兰学者SIBYLLE GRAD(26篇)、瑞士学者ALINI M(22篇)、日本学者MOCHIDA J(19篇)等,中国陆军军医大学周跃教授以19篇并列第4位;总体中国学者在该领域贡献巨大,Top 20中独占9席。从h指数方面比较,日本学者DAISUKE SAKAI以指数19位列首位,其次依次为爱尔兰学者SIBYLLE GRAD(17)、日本学者MOCHIDA J(16)、瑞士学者ALINI M(15)和英国学者HOYLAND JA(14)等,中国学者总体h指数均较低,位居后位。从总被引频次上看,分别为日本学者DAISUKE SAKAI(1 979次)、日本学者MOCHIDA J(1 632次)、英国学者HOYLAND JA(1 370次)、英国学者RICHARDSON SM(1 253次)、爱尔兰学者SIBYLLE GRAD(1 124次)、瑞士学者ALINI M(1 120次)。爱尔兰学者SIBYLLE GRAD学者中心性以0.71系数值显著高于其他作者,中国学者周跃、李方财作者中介中心性值分别为0.13和0.08。可视化图谱可见分别形成了以DAISUKE SAKAI国外学者为中心,以李方财及陈其昕浙江大学团队为中心,以陆军军医大学周跃教授为中心的合作网络,见图12-14。"
2.8.1 作者共被引分析 由于文章所纳入的引文文献数目较多,故将最低被引次数设定为55次,最终12 381作者中共有106篇文献纳入分析。通过VOSviewer对满足阈值106篇引文进行共被引强度以及相关性的分析和可视化图谱绘制。通过VOSviewer对参考文献进行聚类分析,共得到了4个聚类,分别用红、绿、蓝、黄4种颜色表示。红色显示第一聚类,共计37位作者,以GRUBER HE、MASUDA K和ROBERTS S学者为中心;绿色显示第2聚类,共计30位作者,以SAKAI D和VADALA G学者为中心;蓝色显示第3聚类,共计22位作者,以RISBUD MV学者为中心;黄色显示第4聚类,共计17篇文献,以ALINI M学者为中心,见图15,16。"
2.8.2 期刊共被引分析 由于文章所纳入的引文文献数目较多,故将最低被引次数设定为60次,最终2 772本期刊中共有111本期刊纳入分析。通过VOSviewer对满足阈值的111本期刊进行共被引强度以及相关性的分析和可视化图谱绘制。通过VOSviewer对期刊进行聚类分析,共得到了4个聚类,分别用红、绿、蓝、黄4种颜色表示。红色显示第1聚类,共计34本期刊,主要方向为椎间盘退变的细胞生物学研究;绿色显示第2聚类,共计31本期刊,主要方向为椎间盘退变的细胞疗法;蓝色显示第3聚类,共计25本期刊,主要方向为椎间盘退行性改变相关的临床试验;黄色显示第4聚类,共计20本期刊,主要研究为生物材料在椎间盘修复中的应用,见图17,18。"
2.8.3 参考文献共被引 由于文章所纳入的引文文献数目较多,故将最低被引次数设定为40次,最终17 557被引文献中共有103篇文献纳入分析。通过VOSviewer软件对满足阈值103篇引文进行共被引强度以及相关性的分析和可视化图谱绘制。通过VOSviewer对参考文献进行聚类分析,共得到了3个聚类,分别用红、绿、蓝3种颜色表示。红色显示第1聚类,共计48篇文献,主要研究方向为生物材料的椎间盘修复治疗中的应用;绿色显示第2聚类,共计44篇文献,主要研究方向为间充质干细胞在椎间盘内的诱导分化研究;蓝色显示第3聚类,共计11篇文献,主要研究方向为种子细胞移植治疗椎间盘的相关试验研究,见图19,20。"
2.10 研究前沿及趋势在上述对关键词进行聚类分析的基础上,采用Citespace软件突现词功能对干细胞治疗椎间盘退变领域的前沿趋势进行探讨,并绘制突现词图谱,共得到19个突现关键词。右侧红色所占有的时间段即为该关键词持续时间。根据关键词突现强度和持续时间可以对该领域研究方向转变大致分为3个阶段:第1阶段为2004至2007年,主要研究集中在椎间盘发生退变后细胞外基质、蛋白多糖和相关基因表达的变化;第2阶段为2008至2016年,主要研究集中在将骨髓间充质干细胞、软骨终板干细胞等多种种子细胞采用细胞移植方法治疗椎间盘退变疾病;第3阶段从2017至2019年新出现的关键词有5个,分别是“injection”“intervertebral discdegeneration”“inflammation”“apoptosis”“needle puncture”,主要集中在细胞凋亡、炎性反应与椎间盘退变的联系以及细胞移植方法学等方面,见图24。"
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