中国组织工程研究

中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (15): 2303-2307.doi: 10.3969/j.issn.2095-4344.2017.15.002

• 人工假体 artificial prosthesis • 上一篇    下一篇

老年骨质疏松症患者全髋关节置换后应用阿仑膦酸钠维D3

黄飞麒1，2，赵 晓1，姚乃捷1，陈燕梅1   

  1. 1广东药科大学附属第一医院正骨科，广东省广州市 510080；2广州中医药大学，广州中医药大学2016级同等学力申请博士学位人员，广东省广州市  510405
  • 出版日期:2017-05-28 发布日期:2017-06-07
  • 通讯作者: 赵晓，硕士，主治中医师，广东药科大学附属第一医院正骨科，广东省广州市 510080
  • 作者简介:黄飞麒，男，1980年生，广州中医药大学在读博士，主治中医师。
  • 基金资助:

    国家自然科学基金(81674000)

Alendronate sodium/vitamin D3 for senile patients with osteoporosis after total hip arthroplasty

Huang Fei-qi1, 2, Zhao Xiao1, Yao Nai-jie1, Chen Yan-mei1   

  1. 1Department of Bone Orthopedics, the First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China; 2Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Online:2017-05-28 Published:2017-06-07
  • Contact: Zhao Xiao, Master, Attending physician, Department of Bone Orthopedics, the First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China
  • About author:Huang Fei-qi, Studying for doctorate, Attending physician, Department of Bone Orthopedics, the First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China; Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81674000

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515

被引次数

2

摘要：

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文题释义：
阿仑膦酸钠：适用于治疗绝经后妇女的骨质疏松症，以预防髋部和脊柱骨折(椎骨压缩性骨折)，也适用于男性骨质疏松症以增加骨量。
骨密度：即骨骼矿物质密度，是骨骼强度的一个重要指标，以g/cm2表示，是一个绝对值。在临床使用骨密度值时由于不同的骨密度检测仪的绝对值不同，通常使用T值判断骨密度是否正常。T值是一个相对值，正常参考值在-1和+1之间。当T值低于-2.5时为不正常。该值可反映骨质疏松程度，是预测骨折危险性的重要依据。
 
摘要
背景：老年骨质疏松症患者全髋关节置换相关的不良反应较为多见，尤其是假体周围骨密度降低造成的假体松动，甚至会导致翻修。
目的：观察阿仑膦酸钠维D3在老年骨质疏松患者全髋关节置换后的临床疗效及安全性。
方法：将老年骨质疏松患者74例随机分为研究组和对照组，每组37例。两组患者均行全髋关节置换，置换后一两周两组均接受钙剂治疗，研究组患者在此基础上给予阿仑膦酸钠维D3(70 mg)口服，每周1次，两组均连续规律用药6个月。
结果与结论：①骨密度变化：治疗后3，6个月及1年，研究组腰椎及健侧髋部骨密度较治疗前均明显升高(P < 0.05)，且均明显高于对照组(P < 0.05)；②无菌性松动的发生率：两组间假体周围骨折及假体无菌性松动的发生率差异无显著性意义(P > 0.05)；③血肌酐、血磷及血钙水平：两组患者术前与治疗后3，6个月及1年的血肌酐、血磷及血钙水平均在正常范围内，组间及组内治疗前后对比均差异无显著性意义(P > 0.05)；④结果证实：阿仑膦酸钠维D3可有效增加老年骨质疏松患者全髋关节置换后的骨密度，且无明显不良反应，不影响肾功能及钙磷代谢。

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程
ORCID:0000-0002-6745-7967(赵晓)

关键词: 骨科植入物, 人工假体, 全髋关节置换, 骨质疏松症, 阿仑膦酸钠维D3, 骨密度, 假体松动, 老年患者, 假体周围骨折, 血钙, 血磷, 血肌酐, 国家自然科学基金

Abstract:

BACKGROUND: Adverse events following total hip arthroplasty are commonly seen in elderly osteoporotic patients, especially prosthetic loosening caused by reduced bone density surrounding the prosthesis, which even needs reversion.

OBJECTIVE: To investigate the effectiveness and safety of alendronate sodium/vitamin D3 for total hip arthroplasty in elderly patients with osteoporosis.
METHODS: Seventy-four patients with osteoporosis were randomized to experimental and control groups (n=37 per group), and both received total hip arthroplasty, followed by the calcium supplementary treatment at 1-2 weeks. Meanwhile, the patients in the experimental group were orally given alendronate sodium/vitamin D3 (70 mg), once weekly. The course was 6 months in both two groups.
RESULTS AND CONCLUSION: In the experimental group, the bone mineral density of the lumbar vertebrae and contralateral hip were significantly increased at 3, 6 and 12 months postoperatively compared with baseline, and also significantly higher than those in the control group (P < 0.05). (2) The incidence of aseptic loosening and prosthesis adjacent fracture did not differ significantly between two groups (P > 0.05). (3) The serum levels of creatinine, phosphorus and calcium all kept in normal values at baseline and 3, 6 and 12 months postoperatively in both two groups, and showed no significant differences before and after treatment between two groups (P > 0.05). (4) These findings indicate that alendronate sodium/vitamin D3 can effectively increase the bone mineral density of elderly osteoporotic patients after total hip arthroplasty free of significant adverse effects, and exposes no effect on renal function and calcium-phosphorus metabolism.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Tissue Engineering, Hip Joint, Bone Density

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