中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (8): 1203-1209.doi: 10.3969/j.issn.2095-4344.2016.08.021

• 生物材料综述 biomaterial review • 上一篇    下一篇

磷酸钙及硫酸钙支架在骨组织工程中的研究进展

张志达1，江晓兵2，沈耿杨1，任 辉1，杨志东2，崔健超2，陈 康2，唐晶晶2，莫 凌2，林顺鑫1，梁 德2   

  1. 1广州中医药大学第一临床医学院，广东省广州市 510405；2广州中医药大学第一附属医院，广东省广州市 510405
  • 收稿日期:2015-11-25 出版日期:2016-02-19 发布日期:2016-02-19
  • 通讯作者: 梁德，主任医师，广州中医药大学第一附属医院二骨科，广东省广州市 510405
  • 作者简介:张志达，男，1991年生，广东省河源市龙川县人，汉族，广州中医药大学在读硕士，主要从事骨质疏松脊柱伤病研究。
  • 基金资助:
    国家自然科学基金(81503591)；广东省科学技术厅-广东省中医药科学院联合科研项目(2014A020221021)；广东省自然科学基金(2014A030310082)；广东省教育厅学科建设专项基金(育亩工程)[2013LYM-0012]；广州中医药大学优秀青年学者科研基金(KAB110133K04)；广州中医药大学第一临床优博论文培育项目(YB201501)

Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering

Zhang Zhi-da1, Jiang Xiao-bing2, Shen Geng-yang1, Ren Hui1, Yang Zhi-dong2, Cui Jian-chao2, Chen Kang2, Tang Jing-jing2, Mo Ling2, Lin Shun-xin1, Liang De2
  

  1. 1the First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Received:2015-11-25 Online:2016-02-19 Published:2016-02-19
  • Contact: Liang De, Chief physician, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • About author:Zhang Zhi-da, Studying for master’s degree, the First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81503591; the Scientific Research Project of Science and Technology Department of Guangdong Province & Guangdong Provincial Academy of Traditional Chinese Medicine, No. 2014A020221021; the Natural Science Foundation of Guangdong Province, No. 2014A030310082; the Discipline Construction Foundation of Guangdong Provincial Education Department, No. 2013LYM-0012; the Excellent Youth Scholar Foundation of Guangzhou University of Chinese Medicine, No. KAB110133K04; the Youbo Paper Culture Project of the First Clinical College of Guangzhou University of Chinese Medicine, No. YB201501

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摘要：

文章快速阅读：

文题释义：

磷酸钙：化学结构本品为不同形式磷酸钙组成的混合物。不溶于乙醇和丙酮，微溶于水，易溶于稀盐酸和硝酸，可以用作抗结剂、酸度调节剂、营养增补剂、增香剂、稳定剂、水分保持剂。

硫酸钙：为白色单斜结晶或结晶性粉末，无气味，有吸湿性，128 ℃失去1分子结晶水，163 ℃全部失水，溶于酸、硫代硫酸钠和铵盐溶液，在热水中溶解较少，极慢溶于甘油，不溶于乙醇和多数有机溶剂，有刺激性，通常含有2个结晶水，在自然界中以石膏矿形式存在。

 

背景：以磷酸钙和硫酸钙为主要成分，复合其他一种或多种材料来改善或增加骨组织工程支架性能是目前的研究热点。
目的：介绍两种支架在组织工程中的研究进展。
方法：以“骨组织工程，复合支架，磷酸钙，硫酸钙，血管化；bone tissue engineering、composite scaffold，calcium phosphate，calcium sulphate，vascularization”为检索词，应用计算机分别在检索中国期刊全文数据库和PubMed数据库检索2000年1月至2015年6月与骨组织工程相关的文章。

结果与结论：磷酸钙和硫酸钙具备良好的生物相容性、可降解性、骨传导性和完全骨替代性等特性，但单一成分的磷酸钙及硫酸钙均存在一定的缺点，难以完全满足骨缺损修复的要求，通过与不同材料复合，可改进支架的机械强度、可注射性、降解性，优化载药性能和促血管生成等，在基础与临床研究中，应根据治疗的目的来开发理想支架材料。目前绝大多数支架材料还处于体外试验和动物实验阶段，关于不同复合型支架材料的对比研究、复合支架的最佳配比等方面仍待进一步深入研究。 

ORCID: 0000-0002-8009-0282(梁德)

关键词: 生物材料, 材料相容性, 磷酸钙, 硫酸钙, 骨组织工程, 复合支架, 综述, 国家自然科学基金

Abstract:

BACKGROUND: It is a hotspot that calcium phosphate and calcium sulphate as the main ingredients are combined with one or more other materials to improve or increase the performance of bone tissue engineering scaffolds.
OBJECTIVE: To introduce the research advance of these two kinds of scaffolds in bone tissue engineering.
METHODS: The articles related to the bone tissue engineering published during January 2000 to June 2015 were retrieved from CNKI and PubMed databases by computer. The key words were “bone tissue engineering, scaffold, calcium phosphate, calcium sulphate, vascularization” in Chinese and English, respectively.
ESULTS AND CONCLUSION: Calcium phosphate and calcium sulfate are characterized as having good biocompatibility, biodegradability, osteoconductivity and complete bone substitutability. However, single use of calcium phosphate or calcium sulfate scaffold has certain disadvantages, both of which are difficult to fully meet the requirements of the bone defect repair. Improvement can be acquired in the mechanical strength, injectability and biodegradability, as well as drug-loading and pro-angiogenesis of the scaffold in combination with other materials. In the basal and clinical research, we should explore and develop ideal scaffolds in on the basis of therapeutic aim. However, most of the scaffold studies are still at the extracorporeal and animal experiment stage, and the comparative studies on composite scaffolds and optimal proportion of those composite scaffolds still need to be further investigated.