中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (41): 7768-7771.doi: 10.3969/j.issn.2095-4344.2012.41.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

牙周膜干细胞与牙周组织的再生

于海涛，古力巴哈·买买提力   

  1. 新疆医科大学第五附属医院口腔科，新疆维吾尔自治区乌鲁木齐市 830011
  • 收稿日期:2012-05-20 修回日期:2012-07-10 出版日期:2012-10-07 发布日期:2012-10-07
  • 通讯作者: 古力巴哈·买买提力，硕士，主任医师，新疆医科大学第五附属医院口腔科，新疆维吾尔自治区乌鲁木齐市 830011 guli51287@yahoo.com.cn
  • 作者简介:于海涛★，1977年生，山东省威海市人，汉族，2009年新疆医科大学毕业，硕士，主要从事口腔修复的研究。 yht555@yeah.net

Role of periodontal ligament stem cells during regeneration of periodontal tissue

Yu Hai-tao, Maimaitili·Gulibaha   

  1. Department of Stomatology, Fifth Affiliated Hospital of Xinjiang Medical University 830054, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
  • Received:2012-05-20 Revised:2012-07-10 Online:2012-10-07 Published:2012-10-07
  • Contact: Maimaitili·Gulibaha, Master, Chief physician, Department of Stomatology, Fifth Affiliated Hospital of Xinjiang Medical University 830054, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China guli51287@yahoo.com.cn
  • About author:Yu Hai-tao★, Master, Department of Stomatology, Fifth Affiliated Hospital of Xinjiang Medical University 830054, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China yht555@yeah.net

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摘要：

背景：牙周组织再生过程中再生细胞数量和生物学功能的不足是造成组织再生困难的主要原因。
目的：就近年来牙周膜干细胞在牙周组织再生中的研究进展及未来展望作一综述。
方法：由第一作者检索Pubmed 数据库(http://www.ncbi.nlm.nih.gov/pubmed)、中国知网数据库(http://www. cnki.net/)2000年1月至2012年7月 有关牙周膜干细胞分离、鉴定、相关细胞因子等方面的文献，英文检索词为“periodontal ligamentstem cell”，中文检索词为“牙周膜，干细胞”。排除重复性研究，最终纳入26 篇文献进行综述。
结果与结论：利用组织工程的方法，将牙周膜干细胞作为牙周组织再生的种子细胞，在体外培养扩增后移植至缺损区，可有效增进牙周附着结构的再生并缩短愈合周期。对牙周膜干细胞的研究已成为目前牙组织工程领域中的重点课题。

关键词: 牙周膜干细胞, 牙周组织再生, 体外培养, 再生, 组织工程, 干细胞

Abstract:

BACKGROUND: It is difficult to regenerate the periodontal tissue because the number of stem cells is not enough and their biological function is insufficient.
OBJECTIVE: To summarize the progress and perspective of periodontal ligament stem cells for the periodontal tissue regeneration in dentistry.
METHODS: The first author searched PubMed database and CNKI database (2000-01/2012-07) for articles regarding isolation, identification, and relevant factors of periodontal ligament stem cells published between January 2000 and July 2012 using the key words of “periodontal ligament stem cells” in English and “periodontal ligament, stem cells” in Chinese. Repetitive articles were excluded, and 26 articles were included in the final analysis.
RESULTS AND CONCLUSION: Using tissue engineering technology, periodontal ligament stem cells were used as the seed cells of periodontal tissue regeneration and transplanted into the defected area after in vitro culture and amplification. Results showed that periodontal ligament stem cells can promote the regeneration of periodontal attachment tissue and shorten the healing period. The study of periodontal ligament stem cells has become a key point in the field of tooth tissue engineering.

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