中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (36): 6800-6804.doi: 10.3969/j.issn.2095-4344.2012.36.027

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植在心血管疾病应用中急待解决的问题

向 群，陆士娟   

  1. 海口市人民医院心内科，海南省海口市 570208
  • 收稿日期:2012-01-04 修回日期:2012-01-17 出版日期:2012-09-02 发布日期:2012-09-02
  • 作者简介:向群★，女，湖南省双峰县人，汉族，中南大学湘雅医学院在读硕士，医师，主要从事心内科导管介入研究。 lengyanlove@126.com

Problems to be solved in stem cell transplantation for treatment of cardiovascular disease

Xiang Qun, Lu Shi-juan   

  1. Department of Cardiology, Haikou People’s Hospital, Haikou 570208, Hainan Province, China
  • Received:2012-01-04 Revised:2012-01-17 Online:2012-09-02 Published:2012-09-02
  • About author:Xiang Qun★, Studying for master’s degree, Physician, Department of Cardiology, Haikou People’s Hospital, Haikou 570208, Hainan Province, China lengyanlove@126.com

PDF

464

被引次数

3

摘要：

背景：干细胞作为细胞移植的种子细胞治疗心血管疾病已成为近年来研究的热点，许多动物实验及临床研究均表明干细胞移植是提高心功能新的治疗措施。
目的：针对干细胞在心血管疾病应用中的移植种类选择、移植途径、移植时机及其安全性问题进行综述。
方法：由第一作者应用计算机检索2000/2010 PubMed数据库及中国期刊全文数据库中有关干细胞移植在心血管疾病中应用的文章，英文检索词为“stem cell transplantion，cardiovascular disease”，中文检索词为“干细胞移植，心血管疾病”。排除重复性研究及无关研究，共保留25篇文章进行综述。
结果与结论：干细胞移植可以改善缺血心肌的灌注，减少心肌细胞死亡，限制左室重构，从而从根本上改善患者的心功能，降低死亡率。但干细胞移植治疗心血管疾病的研究目前还处于初级阶段，尚有许多问题急待解决。

关键词: 干细胞, 移植, 心血管疾病, 组织工程, 综述文献

Abstract:

BACKGROUND: Stem cells as seed cells for cell transplantation treatment of cardiovascular diseases has become a hot topic in recent years and many animal models and clinical studies have indicated that stem cell transplantation will be a new treatment to improve the heart function.
OBJECTIVE: To review the issues on transplantation type selection, transplantation path, transplantation occasion and safety for the application of stem cells in cardiovascular disease.
METHODS: A computer-based online retrieval of PubMed and CNKI was performed to search manuscripts addressing stem cell transplantation for treatment of cardiovascular disease published in 2000/2010 in English and Chinese with the key words “stem cell transplantation, cardiovascular disease”. Repetitive research and non-related studies were excluded, and 25 articles were included in this review.
RESULTS AND CONCLUSION: Stem cell transplantation can improve perfusion of ischemic myocardium, reduce the death of myocardial cells, and limit left ventricular remodeling, which will fundamentally improve cardiac function and reduce mortality. However, the research on the treatment of cardiovascular disease with stem cell transplantation is still in its infancy and there are still many problems to be solved.

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