中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (29): 5477-5480.doi: 10.3969/j.issn.2095-4344.2012.29.032

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

胶原/壳聚糖止血敷料在外科伤口中的应用

高文彪，张岩睿，张 军   

  1. 新疆医科大学第六附属医院普外科，新疆维吾尔自治区乌鲁木齐市 830002
  • 收稿日期:2012-03-19 修回日期:2012-05-15 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 张军，副主任医师，新疆医科大学第六附属医院普外科，新疆维吾尔自治区乌鲁木齐市 830002 zhangjun52288@163.com
  • 作者简介:高文彪，男，1964年生，山东省龙口县人，汉族，1989年新疆医科大学毕业，副主任医师，主要从事胃肠肿瘤专业的研究。 1316324939@ qq.com

Collagen/chitosan hemostatic dressings in surgical wounds

Gao Wen-biao, Zhang Yan-rui, Zhang Jun   

  1. Department of General Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • Received:2012-03-19 Revised:2012-05-15 Online:2012-07-15 Published:2012-07-15
  • Contact: Zhang Jun, Associate chief physician, Department of General Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China zhangjun52288@ 163.com
  • About author:Gao Wen-biao, Associate chief physician, Department of General Surgery, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, Xinjiang Uygur Autonomous Region, China 1316324939@ qq.com

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1142

被引次数

23

摘要：

背景：壳聚糖与胶原联合可更有效地止血。
目的：评价胶原/壳聚糖止血敷料的材料学性能及应用于外科伤口的生物相容性。
方法：以“生物材料，止血敷料，纱布，胶原/壳聚糖，生物相容性”为中文关键词，以“biomaterial；hemostatic material；bioresorbable material；hemostasis effect；hemostatic mechanism”为英文关键词，采用计算机检索2000-01/2010-06与生物敷料、胶原/壳聚糖止血材料在伤口或创面止血过程中应用相关的文献。
结果与结论：壳聚糖独特的生物学特性，具有广谱抑菌、促进上皮细胞生长及止血，促进创面愈合的作用，在体内具有良好的生物降解性与组织相容性，可用于指端损伤和肉芽创面的治疗，如制成伤口敷料、可吸收缝线、止血材料、防粘连剂、药物缓释及组织工程支架，用于平战时伤口的处理。

关键词: 胶原/壳聚糖, 生物材料, 止血, 敷料, 生物相容性

Abstract:

BACKGROUND: Chitosan combined with collagen can be more effective to stop the bleeding.
OBJECTIVE: To assess the material properties and biocompatibility of collagen/chitosan hemostatic dressing materials in surgical wounds.
METHODS: A computer-based search was performed for articles addressing biological dressings, collagen/chitosan hemostatic materials in wounds or during wound hemostasis published from January 2000 to June 2010. The keywords were “biomaterial, hemostatic material, gauze, collagen/chitosan, biocompatibility” in Chinese and “biomaterial, hemostatic material, bioresorbable material, hemostasis effect, hemostatic mechanism” in English.
RESULTS AND CONCLUSION: Chitosan has unique biological properties that are characterized to have a broad-spectrum antibacterial activity, to promote epithelial cell growth and hemostasis, promote wound healing, and have a good biodegradability and tissue compatibility, which can be used for treatment of fingertip injury and granulation wound. Chitosan can be applied to prepare wound dressings, absorbable sutures, hemostatic materials, anti-blocking agent, drug delivery and tissue engineering scaffolds for wound treatment under field conditions.

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