中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (26): 4133-4138.doi: 10.3969/j.issn.2095-4344.0942

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

基于Mimics测量CT扫描数据二段可调式新型纳米羟基磷灰石/聚酰胺66复合材料人工假体的设计

陈广辉1,成 立2,王 健3,黄 权1,白广建4,尹萌辰5,魏海峰1,杨 诚1,肖建如1,刘铁龙1   

  1. 1上海长征医院骨肿瘤科,上海市 200003;2慈溪市人民医院骨科,浙江省慈溪市 315300;3上海浦东新区人民医院骨科,上海市 200000;4泰山医学院,山东省泰安市 271016;5上海市龙华医院骨科,上海市 200000
  • 收稿日期:2018-04-03 出版日期:2018-09-18 发布日期:2018-09-18
  • 通讯作者: 刘铁龙,博士,副主任医师。上海长征医院骨肿瘤科,上海市 200003
  • 作者简介:陈广辉,男,1988年生,山东省滨州市人,汉族, 2017年泰山医学院毕业,硕士,医师。
  • 基金资助:

    国家自然科学基金面上项目(51573207);宁波市自然科学基金(2016A610006)

Design of a novel two-segment adjustable nano-hydroxyapatite/polyamide 66 artificial prosthesis based on Mimics measurements of CT scan data

Chen Guang-hui1, Cheng Li2, Wang Jian3, Huang Quan1, Bai Guang-jian4, Yin Meng-chen5, Wei Hai-feng1, Yang Cheng1, Xiao Jian-ru1 Liu Tie-long1   

  1. 1Department of Oncology, Changzheng Hospital, Second Military Medical University of PLA, Shanghai 200003, China; 2Department of Orthopedics, Cixi People’s Hospital, Cixi 315300, Zhejiang Province, China; 3Department of Orthopedics, People’s Hospital of Shanghai Pudong District, Shanghai 200000, China; 4Taishan Medical University, Taian 271016, Shandong Province, China; 5Department of Orthopedics, Longhua Hospital, Shanghai 200000, China
  • Received:2018-04-03 Online:2018-09-18 Published:2018-09-18
  • Contact: Liu Tie-long, M.D., Associate chief physician, Department of Oncology, Changzheng Hospital, Second Military Medical University of PLA, Shanghai 200003, China
  • About author:Chen Guang-hui, Master, Physician, Department of Oncology, Changzheng Hospital, Second Military Medical University of PLA, Shanghai 200003, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51573207; Ningbo Natural Science Foundation, No. 2016A610006

摘要:

文章快速阅读:

 

文题释义:
椎体终板:是椎体在生长发育过程中,椎体上下面的骨骺板骨化停止后形成骨板,呈轻度凹陷,即为骨性终板。椎体终板构成了椎间盘的上下边界,位于椎体中心的松质骨和椎间盘之间。
软骨终板:椎体终板的中央仍为一薄层透明软骨覆盖,并终生存在,即为软骨终板,上下软骨终板与髓核和纤维环连接共同构成椎间盘。
 
 
背景:目前临床常用的脊柱修复重建假体由于其具有材质刚度较大且与相邻终板接触面积太小等缺点,易产生应力遮挡,导致术后骨折不愈合及局部骨质吸收等问题的发生。随着固定时间的不断延长,内固定易出现疲劳性断裂,导致内固定失败。
目的:利用Mimics软件测量腰椎的CT扫描数据设计二段可调式新型人工假体。
方法:选取60例中青年男性住院患者腰椎CT扫描数据,导入Mimics软件中进行骨骼轮廓提取划分,分别测量记录L1-3椎体高度及上下终板横径、矢状径、矢状面凹陷角及冠状面凹陷角等指标,依照所测数据设计高度可调且两端接触面与相邻椎体终板相贴合的新型人工假体。

结果与结论:①利用Mimics软件精确划分提取了所有病例资料的L1-3椎体数据。经过测量分析,L1-3椎体高度,上下终板矢状径及矢状面凹陷角差异无显著性意义,L1-3椎体上终板横径均小于同椎体下终板(P < 0.05),冠状面凹陷角差异明显(P < 0.05);②根据所测椎体高度及终板矢状径、矢状面凹陷角等数据结果设计出高度可调新型人工假体。该假体以纳米羟基磷灰石/聚酰胺66复合材料为基础,由顶盖和底座两部分相互嵌套组成,术中可通过底座侧孔注入骨水泥实现假体高度调节。该假体两端接触面与相邻终板紧密贴合、足够的接触面积能有效减少应力集中,促进假体与终板的骨质愈合;③结果说明,试验利用Mimics软件测量腰椎的CT扫描数据设计二段可调式新型人工假体设计合理,操作方便。

ORCID: 0000-0002-3119-2784(陈广辉)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 椎体高度, 终板形态学, 解剖学, CT扫描, 纳米羟基磷灰石/聚酰胺66复合材料, 生物材料, 人工假体, Mimics, 矢状径, 终板横径, 组织工程

Abstract:

BACKGROUND: Previous studies have shown that commonly used prostheses for spinal repair are prone to have stress shielding effects (nonunion and local bone resorption) due to their limited high elastic modulus and limited contact areas, which can lead to the failure of internal fixation over time.

OBJECTIVE: To design a novel two-segment adjustable artificial vertebral body through the measurement of CT scan data of the vertebral body using Mimics software.
METHODS: Sixty young and middle-aged male patients with lumbar CT scan data were included. Mimics software was used to extract the skeleton contour of L1-3 vertebrae and to measure the vertebral body height and the transverse diameter of the upper and lower end plates, sagittal diameter, sagittal and coronal concave angles. Based on the measured data, a new type of artificial vertebral body adjustably and anatomically fitting the vertebral endplate was designed.

RESULTS AND CONCLUSION: There was no significant difference in the L1-3 height and sagittal diameter of the upper and lower endplates, and sagittal concave angle among all the cases. The transverse diameter of the upper endplate was significantly less than that of the lower endplate in the same vertebra (P < 0.05). A significant difference in the sagittal concave angle was also found (P < 0.05). Based on the measured vertebral height, sagittal diameter of the endplate and sagittal concave angle, a novel artificial vertebral body with adjustable height was designed. The new product made of nano-hydroxyapatite/polyamide 66 was composed of a top cover and a base. The height of the designed vertebral body could be controlled by bone cement injection via the side hole on the base. And it could be tightly integrated with the upper and lower endplates of the adjacent vertebral body, which is beneficial to promote the osseointegration. In conclusion, the two-segment adjustable artificial vertebral body has the advantages of reasonable design and convenient operation.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Tissue Engineering, Biocompatible Materials, Lumbar Vertebrae

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