中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (14): 2239-2244.doi: 10.3969/j.issn.2095-4344.0788

• 生物材料综述 biomaterial review • 上一篇    下一篇

干细胞复合三维支架治疗骨质疏松性骨缺损

袁伟健,王辰宇,李 忱,杨 帆,王中汉,李祖浩,秦彦国,刘 贺,王金成   

  1. 吉林大学第二医院骨科,吉林省长春市 130041
  • 收稿日期:2018-01-16 出版日期:2018-05-18 发布日期:2018-05-18
  • 通讯作者: 王金成,主任医师,教授,博士生导师,吉林大学第二医院骨科,吉林省长春市 130041
  • 作者简介:袁伟健,男,1992 年生,汉族,吉林大学第二医院骨科在读硕士,主要从事骨质疏松方面应用的研究。
  • 基金资助:

    国家自然科学基金项目(81671804);吉林省自然科学基金项目(20160101109JC,20150414006GH,20150312028ZG,20130206060GX);吉林大学白求恩医学部博士研究生优秀拔尖人才培育计划项目(YB201501);吉林大学研究生创新研究计划项目(2016041,2016108)

Stem cells combined with three-dimensional scaffolds for the treatment of osteoporotic bone defects

Yuan Wei-jian, Wang Chen-yu, Li Chen, Yang Fan, Wang Zhong-han, Li Zu-hao, Qin Yan-guo, Liu He,   Wang Jin-cheng   

  1. Department of Orthopedics, Second Hospital of Jilin University, Chuangchun 130041, Jilin Province, China
  • Received:2018-01-16 Online:2018-05-18 Published:2018-05-18
  • Contact: Wang Jin-cheng, Chief physician, Professor, Doctoral supervisor, Department of Orthopedics, Second Hospital of Jilin University, Chuangchun 130041, Jilin Province, China
  • About author:Yuan Wei-jian, Master candidate, Department of Orthopedics, Second Hospital of Jilin University, Chuangchun 130041, Jilin Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81671804; the Natural Science Foundation of Jilin Province, No. 20160101109JC, 20150414006GH, 20150312028ZG, 20130206060GX; the Excellent Doctoral Candidate Incubation Program in Norman Bethune Health Science Center of Jilin University, No. YB201501; the Postgraduate Innovation Research Program of Jilin University, No. 2016041, 2016108

摘要:

文章快速阅读:

 

文题释义:
三维支架:具有三维空间结构,支架除了提供一定的机械强度外,具有生物相容性和生物降解性及多孔的特性能,够为修复骨缺损的相关细胞附着和生长提供了一个有利微环境,对骨缺损的修复起到积极作用。
骨质疏松症:是以骨量减少、骨的微观结构退化为特征,致使骨的脆性增加及易于发生骨折的一种全身性骨骼疾病。骨质疏松性骨折是骨质疏松症最严重的后果,其特点是:骨质量差,骨折愈合时间迟缓,再骨折的发生率较高。由于骨的质量差,导致骨折后内固定植入物的牢固程度较差,易发生松动。
 
 
背景:对于骨质疏松性骨缺损,干细胞复合三维支架治疗方法具有极大的潜力。
目的:介绍干细胞复合三维支架在修复骨质疏松性骨缺损方面的作用。
方法:作者以“stem cells,scaffold,osteoporosis,bone defects”为关键词,检索2007至2017年PubMed、Web of Science、Springerlink、Medline数据库中相关文献;以“干细胞,支架,骨质疏松,骨缺损”为关键词,检索2007至2017年万方、中国知网数据库中相关文献。初检到文章142篇,筛选后对45篇文章进行分析。

结果与结论:由于干细胞具有自我更新和多向分化的潜能,可用于修复或再生受损组织,被认为是作为细胞替代疗法治疗骨科疾病的理想细胞来源。在治疗骨质疏松性骨缺损过程中,干细胞-三维支架复合体中的支架除了提供一定的机械强度外,还为修复的相关细胞、因子提供一个有利的再生微环境,复合体更重要的作用是调节骨代谢,促进骨缺损的愈合,起到更好的修复作用。此外,结合基因治疗,基因修饰的干细胞复合三维支架对于骨质疏松相关骨缺损的重建具有巨大的潜力。总之,干细胞复合三维支架为骨质疏松性骨缺损的治疗提供了一种新思路,可能成为未来的治疗策略之一。

ORCID: 0000-0002-7864-7811(袁伟健)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 三维支架, 骨质疏松, 骨缺损, 修复, 综述, 国家自然科学基金, 生物材料, 干细胞

Abstract:

BACKGROUND: Stem cells combined with a three-dimensional scaffold have great potential for the treatment of osteoporotic bone defects.

OBJECTIVE: To introduce the application of stem cells combined with the three-dimensional scaffold in repairing osteoporotic bone defects.
METHODS: A computer-based search of PubMed, Web of Science, Springerlink, Medline, WanFang and CNKI databases was performed for relevant articles published from 2007 to 2017 with “stem cells, scaffold, osteoporosis, bone defects” as key words in English and Chinese, repsectively. Initially, 142 articles were retrieved, and finally 45 articles were included in result analysis.

RESULTS AND CONCLUSION: Due to the potential of self-renewal and multilineage differentiation, stem cells can be used to repair or regenerate damaged tissues, which are considered as an ideal cell source for the treatment of diseases in orthopedics. The suitable scaffold can provide a favorable microenvironment for repairing the attachment and growth of the cells related to the bone defect, which can promote the healing without additional side effects. Furthermore, stem cells combined with three-dimensional scaffolds provide a promising clinical application for the treatment of osteoporotic bone defects by regulation of bone metabolism. In addition, gene-modified stem cells with three-dimensional scaffolds bring a huge potential in the treatment of osteoporotic bone defects. In conclusion, the combination of stem cells and three-dimensional scaffolds provides a new approach for the treatment of osteoporotic bone defects, which may be one of the future therapeutic strategies.

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Stem Cells, Osteoporotic Fractures, Compomers, Tissue Engineering

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