中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (12): 2241-2244.doi: 10.3969/j.issn.1673-8225.2012.12.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

人工韧带材料与膝关节韧带损伤★

康建敏1，左  健2   

  1. 1河北经贸大学体育教学部，河北省石家庄市      050061；2石家庄学院体育系，河北省石家庄市  050035
  • 收稿日期:2011-12-10 修回日期:2012-02-15 出版日期:2012-03-18 发布日期:2012-03-18
  • 作者简介:康建敏★，男，1971年生，河北省灵寿县人，汉族，1996年河北师范大学毕业，硕士，副教授，主要从事体育教育训练学、运动康复医学研究。 kjm1971@ 126.com

Artificial ligament materials and ligament injury of the knee joint 

Kang Jian-min1, Zuo Jian2   

  1. 1Department of Physical Education, Hebei University of Economics and Business, Shijiazhuang  050061, Hebei Province, China;    2Department of Physical Education, Shijiazhuang University, Shijiazhuang  050035, Hebei Province, China
  • Received:2011-12-10 Revised:2012-02-15 Online:2012-03-18 Published:2012-03-18
  • About author:Kang Jian-min★, Master, Associate professor, Department of Physical Education, Hebei University of Economics and Business, Shijiazhuang 050061, Hebei Province, China kjm1971@126.com

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摘要：

背景：目前临床重建膝关节交叉韧带使用的材料包括自体移植物、异体移植物和人工合成材料。自体和异体移植物重建交叉韧带依然是目前的主流选择，但均存在各自的缺点。
目的：探讨膝关节韧带损伤人工合成材料的优化选择策略。
方法：由作者采用电子检索的方式，在万方数据库(http://www.wanfangdata.com.cn/)及PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)中检索1988-01/2010-12有关人工韧带生物工程学设计及临床应用的研究文章，检索词为“人工韧带，材料，组织工程，重建”。经检索排除内容重复、Meta分析类文章后筛选纳入20篇文献进行评价。
结果与结论：目前组织工程人工韧带在某些方面取得了一定的进展，但在很多方面仍需进一步研究。种子细胞的选择支架材料的组织相容性和力学性质的统一，细胞和支架材料界面生物相容性的不确定性等是组织工程韧带的研究热点和趋势。随着研究的深入，组织工程人工韧带有望尽早得到临床使用。
关键词：人工韧带；膝关节；材料；组织相容性；组织工程
doi:10.3969/j.issn.1673-8225.2012.12.035

关键词: 人工韧带, 膝关节, 材料, 组织相容性, 组织工程

Abstract:

BACKGROUND: Current used materials for clinical reconstruction of cruciate ligaments of knee joint include autograft, allograft and artificial materials. Autograft and allograft are main selection for reconstruction of cruciate ligaments. However, there are some limitations.
OBJECTIVE: To discuss optimal selection of artificial materials for ligament injury of the knee joint.
METHODS: A computer-based online search of Wanfang database (http://www.wanfangdata.com.cn/) and PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) was performed for articles related to bioengineering design and clinical application of artificial ligaments published between January 1988 and December 2010 with key words “artificial ligament, tissue engineering, reconstruction”. After excluding repetitive and Meta analysis articles, 20 were included for further analysis.
RESULTS AND CONCLUSION: Although there are progresses in artificial ligament, some issues are needed to resolve. Seed cell selection, histocompatibility and mechanics of stent materials, cell and stent material interface biocompatibility are focuses in studies regarding artificial ligaments. With further investigation, tissue engineered artificial ligaments can be clinically used early.

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