中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (51): 9659-9662.doi: 10.3969/j.issn.1673-8225.2011.51.038

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

生物可降解材料在眼科临床中的应用

赵  玲   

  1. 沈阳医学院附属沈洲医院眼科，辽宁省沈阳市    110002
  • 收稿日期:2011-08-06 修回日期:2011-10-09 出版日期:2011-12-17 发布日期:2011-12-17
  • 作者简介:赵玲★，女，1972年生，辽宁省沈阳市人，汉族，2008年吉林大学基础医学院毕业，硕士，副主任医师，主要从事青光眼的神经病理机制研究。 zhaolsy1@ 126.com

Biodegradable materials in clinical ophthalmology

Zhao Ling   

  1. Department of Ophthalmology, Shenzhou Hospital of Shenyang Medical College, Shenyang  110002, Liaoning Province, China
  • Received:2011-08-06 Revised:2011-10-09 Online:2011-12-17 Published:2011-12-17
  • About author:Zhao Ling★, Master, Associate chief physician, Department of Ophthalmology, Shenzhou Hospital of Shenyang Medical College, Shenyang 110002, Liaoning Province, China zhaolsy1@126.com

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535

被引次数

3

摘要：

背景：组织工程化材料在眼科应用较少，尤其在眼表重建中大部分材料还处于动物实验阶段，尚有许多亟需解决的问题。
目的：评价生物可降解材料在眼科中的应用，以寻找合理的眼科材料。
方法：采用电子检索的方式，在万方数据库(http://www.wanfangdata.com.cn/)及Pubmed数据库(http://www.ncbi.nlm.nih. gov/pubmed)中检索1999-01/2009-12有关生物可降解材料应用于眼科临床的研究文章，关键词为“组织工程，眼科，生物材料”。排除重复研究、普通综述或Meta分析类文章，筛选纳入17篇文献进行评价。
结果与结论：生物可降解材料具有生物屏障作用，能促进上皮细胞增长，抑制成纤维细胞生长，减少胶原纤维合成，减少手术创面出血，达到防止粘连的目的，还有抑菌、增强免疫力、促进伤口愈合的功能。故在眼科疾病治疗中可单独用作眼外伤或术后炎症、纤维增生性病变的治疗药物，也有可能用于眼部整形。随着生物医学和材料学的进一步结合，生物可降解材料在眼科领域的研究将会越来越广泛和深入。可以预见，生物可降解材料一旦工业化，在生物医学方面将会有非常广阔的应用前景。

关键词: 透明质酸钠, 壳聚糖, 生物相容性, 眼科, 组织工程

Abstract:

BACKGROUND: Tissue-engineered materials are rarely applied in ophthalmology, especially in ocular surface reconstruction. Most materials are still in animal testing, and there are many urgent problems.
OBJECTIVE: To assess the application of biodegradable materials in ophthalmology in order to find the rational ophthalmic materials.
METHODS: A computer-based search of Wanfang (http://www.wanfangdata.com.cn/) and PubMed (http://www.ncbi.nlm.nih.gov/ pubmed) was performed to retrieve articles published 1999-01/2009-12 addressing the clinical application of biodegradable materials in ophthalmology. The key words were “tissue engineering, ophthalmology, biomaterial” in Chinese and English. Repetitive articles and Meta analyses were excluded, and finally 17 articles were included in result analysis.
RESULTS AND CONCLUSION: Biodegradable materials functioned as biological barriers can promote epithelial cell growth, inhibit fibroblast growth, reduce collagen synthesis, reduce surgical wound bleeding so as to prevent adhesion, as well as have antibacterial function, enhance immunity, and promote wound healing. Therefore, the biodegradable materials can be used alone to treat postoperative inflammation and fibrous proliferative lesions, and they can be also applied for eye surgery. With the further integration of biomedicine and materials science, the application of biodegradable materials is increasingly prevalent in ophthalmic research. It is conceivable that once the biodegradable materials are industrialized, they will have very broad application prospects in biomedicine.

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