中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9299-9302.doi: 10.3969/j.issn.1673-8225.2011.49.042

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

心脏干细胞的研究与进展

杨文玲，赵晓辉   

  1. 解放军第三军医大学新桥医院心内科，重庆市   400037
  • 收稿日期:2011-06-21 修回日期:2011-07-18 出版日期:2011-12-03 发布日期:2011-12-03
  • 通讯作者: 赵晓辉，博士，副教授，解放军第三军医大学新桥医院心内科，重庆市 400037
  • 作者简介:杨文玲，女，1985年生，重庆市人，汉族，2010年解放军第三军医大学毕业，医师，主要从事心血管内科学研究。

Research advances in cardiac stem cells

Yang Wen-ling, Zhao Xiao-hui   

  1. Department of Cardiology, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing  400037, China
  • Received:2011-06-21 Revised:2011-07-18 Online:2011-12-03 Published:2011-12-03
  • Contact: Zhao Xiao-hui, Doctor, Associate professor, Department of Cardiology, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing 400037, China zxhwn2002@yahoo.com.cn
  • About author:Yang Wen-ling, Physician, Department of Cardiology, Xinqiao Hospital, Third Military Medical University of Chinese PLA, Chongqing 400037, China reynold52@163.com

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351

被引次数

2

摘要：

背景：大量研究证明，哺乳动物心脏中存在心脏自身干细胞，参与心脏的自我更新和内源性修复。
目的：就心脏干细胞的来源、分类、特征及心脏病治疗等方面进行综述。
方法：由第一作者应用计算机检索PubMed数据库2000-01/2010-12有关心脏干细胞的来源、分化、特征及其在心肌再生方面的文章，检索词为“Cardiac stem cell”，包括临床研究和基础研究，排除重复研究和Meta 分析，共保留32篇文献进行综述。
结果与结论：心脏干细胞是一类存在于心脏组织内能够自我更新及克隆增殖的干细胞，它能够分化为心肌细胞、内皮细胞，参与心脏损伤修复，改善心功能。现已能够通过体外分离培养扩增后移植入动物心脏内，为下一步在临床上应用于人体打下了基础。但成体心脏干细胞自身的稳态平衡和动态变化，及其向心脏功能细胞分化需经历哪些具体过程，有哪些影响因素及如何调控等还不太清楚，需要继续研究以进一步证实。

关键词: 心脏干细胞, 心肌细胞, 定向分化, 心脏疾病, 干细胞移植

Abstract:

BACKGROUND: A large amount of studies have demonstrated that stem cells in the heart of mammal participate in heart self-renewal and endogenous repair.
OBJECTIVE: To summarize the source, classification, features of cardiac stem cells and application in heart disease.
METHODS: A computer-based online search of PubMed database was performed for articles published between January 2000 and December 2010 related to the source, classification, features of cardiac stem cells and its effects on myocardial regeneration with key words “cardiac stem cell”. Clinical studies and basic studies were all included. Repetitive studies and Meta analysis were excluded. Finally, 32 articles were included.
RESULTS AND CONCLUSION: Cardiac stem cell is a type of stem cells in the heart, with properties of self-renewal and cloning proliferation. It can differentiate into cardiomyocyte and endothelial cell and plays a role in heart injury repair to improve heart function. Cardiac stem cells have been in vitro isolated, cultured and amplified to transplant into animal heart, which lays a foundation for clinical application. However, some questions remain poorly understood as to the homeostasis and dynamic changes, processes involved in their differentiation into heart functioning cells, as well as influential factors and regulation.

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