中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (49): 9295-9298.doi: 10.3969/j.issn.1673-8225.2011.49.041

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

表皮细胞去分化的表皮干细胞

赵学凯，梁自乾，张宪发，宗守凯   

  1. 广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-06-16 修回日期:2011-10-10 出版日期:2011-12-03 发布日期:2011-12-03
  • 通讯作者: 通讯作者：梁自乾，教授，硕士生导师，广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市 530021 Liangzqian@yahoo.com.cn
  • 作者简介:赵学凯★，男，1985年生，山东省滨州市人，汉族，广西医科大学在读硕士，主要从事创面愈合、表皮干细胞的研究。 zhaoxuekai3581@163.com

Mature epidermal cells dedifferentiate towards epidermal stem cells

Zhao Xue-kai, Liang Zi-qian, Zhang Xian-fa, Zong Shou-kai   

  1. Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-16 Revised:2011-10-10 Online:2011-12-03 Published:2011-12-03
  • Contact: Liang Zi-qian, Professor, Master’s supervisor, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China Liangzqian@yahoo.com.cn
  • About author:Zhao Xue-kai★, Studying for master’s degree, Department of Burn and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zhaoxuekai3581@163.com

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摘要：

背景：表皮干细胞以显著的自我更新和多向分化潜能及皮肤组织工程学中诱人的应用前景，作为“种子细胞”成为皮肤创伤研究领域的热点之一。
目的：综述表皮细胞去分化逆转为表皮干细胞的研究近况。
方法：应用计算机检索1998-01/2011-01 PubMed、Highwire和中国期刊全文数据库相关文章，检索词“dedifferentiation，epidermal cells，epidermal stem cells，induction，去分化，表皮细胞，表皮干细胞，诱导”。共检索到文献2 754篇，最终纳入符合标准的文献46篇。
结果与结论：去分化来源的表皮干细胞与机体自身来源的表皮干细胞之间在形态学和功能有许多相似点，并可表达表皮干细胞的特异性标记物。表皮细胞去分化途径制造表皮干细胞，可以作为机体自身来源表皮干细胞的替代细胞应用于皮肤损伤重建和再生的相关研究，为实现皮肤创伤由解剖修复到功能修复的“完美修复”提供新思路。

关键词: 表皮细胞, 去分化, 表皮干细胞, 诱导, 皮肤组织工程, 创面愈合, 综述文献

Abstract:

BACKGROUND: Epidermal stem cells as seed cells have been paid great attention on the research of wound repair and regeneration with its specific biological advantages with the development of molecular biology and bioengineering.
OBJECTIVE: To review the recent advances in the mature epidermal cells dedifferentiating towards epidermal stem cells.
METHODS: The first author retrieved PubMed database, Highwire database (Highwire.standford.edu) and CNKI for articles published from January 1998 to January 2011. The key words were “dedifferentiation, epidermal stem cell, epidermal cell, induction” in English and Chinese. A total of 2 754 literatures were collected, and finally 46 papers were included in result analysis.
RESULTS AND CONCLUSION: The dedifferentiated epidermal stem cells have some characteristics of native epidermal stem cells and perhaps they may act as a new vehicle for wound repair and regeneration. Both of the native epithelial stem cells and the dedifferentiated epithelial stem cells can promote the wound repair and their effects were on the same level. Because differentiation from epidermal cells into epidermal stem cells has many questions, so far, there are many animal researches, but its extensive clinical application deserves further development.

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