中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8899-8902.doi: 10.3969/j.issn.1673-8225.2011.47.040

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

医用生物材料在肌腱损伤后粘连修复中的应用

靳  冬，张果忠   

  1. 武装警察部队医学院附属医院中医康复理疗科，天津市  300162
  • 收稿日期:2011-06-10 修回日期:2011-08-15 出版日期:2011-11-19 发布日期:2011-11-19
  • 通讯作者: 张果忠，武装警察部队医学院附属医院中医康复理疗科，天津市 300162
  • 作者简介:靳冬☆，男，1981年生，河北省定州市人，汉族，2010年天津中医药大学毕业，博士，医师，主要从事中医理论及临床研究。 jd532@126.com

Biomedical materials for adhesion repair after tendon injury

Jin Dong, Zhang Guo-zhong   

  1. Department of Traditional Chinese Medicine Rehabilitation, Affiliated Hospital, Medical College of Chinese Armed Police Force, Tianjin  300162, China
  • Received:2011-06-10 Revised:2011-08-15 Online:2011-11-19 Published:2011-11-19
  • Contact: Zhang Guo-zhong, Department of Traditional Chinese Medicine Rehabilitation, Affiliated Hospital, Medical College of Chinese Armed Police Force, Tianjin 300162, China
  • About author:Jin Dong☆, Doctor, Physician, Department of Traditional Chinese Medicine Rehabilitation, Affiliated Hospital, Medical College of Chinese Armed Police Force, Tianjin 300162, China

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372

被引次数

3

摘要：

背景：选用何种生物材料预防肌腱粘连，是目前医学界研究的热点。
目的：总结近年生物材料在肌腱损伤术后粘连修复中的应用现状。
方法：由作者应用计算机检索1999-01/2009-10维普数据库，选择生物材料修复肌腱损伤术后粘连的有关文章，共入选相关文献30篇。
结果与结论：几丁糖具有良好的生物学特性，是一种无毒、无刺激性、无抗原性、组织相容性良好、在体内可降解吸收的新型医用生物材料，具有显著预防肌腱粘连作用。医用生物蛋白胶具有优良的止血与封闭作用、良好的生物相容性、生物降解功能，一定的杀菌作用，可减少和控制创伤炎症反应。大量临床研究及动物实验研究显示医用透明质酸钠、明胶海绵、糜蛋白酶等均具有防止术后组织粘连的作用。

关键词: 生物材料, 肌腱损伤, 术后粘连, 修复, 生物相容性

Abstract:

BACKGROUND: Selection of biomaterials against tendon adhesion is a hotspot in the medical field.
OBJECTIVE: To summarize the clinical application of biomaterials in adhesion repair following tendon injury.
METHODS: A computer-based search of VIP database (1999-01/2009-10) was performed for articles about biomaterials for postoperative adhesions after tendon injury. Totally 30 articles were included.
RESULTS AND CONCLUSION: Chitosan has good biological properties, which is a non-toxic, non-irritating, non-antigenic, and biodegradable biomaterial with good tissue compatibility, and it has a significant role in the prevention of tendon adhesion. Biomedical fibrin glue has a fine hematischesis and sealing function, good biocompatibility, favorable biodegradation function and a certain sterilization, which can reduce and control traumatic inflammation reactions. Numerous clinical studies and animal studies have shown that medical sodium hyaluronate, gelatin sponge, and chymotrypsin have a preventive role in postoperative tissue adhesion.

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