中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8859-8862.doi: 10.3969/j.issn.1673-8225.2011.47.029

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

不同修饰剂对水热法制备羟基磷灰石粒径大小的影响

吴占敖，宣志刚，王春凤，刘  姒，孙  敏   

  1. 解放军第359医院，江苏省镇江市212001
  • 收稿日期:2011-07-25 修回日期:2011-10-08 出版日期:2011-11-19 发布日期:2011-11-19
  • 作者简介:吴占敖，男，1966年生，江苏省宜兴市人，汉族， 1991年解放军第四军医大学毕业，副主任医师，主要从事口腔医学方面的研究。 wuxiaoliang98@yahoo.com.cn

Effect of organic modifiers on the size of hydroxyapatite prepared by hydrothermal method

Wu Zhan-ao, Xuan Zhi-gang, Wang Chun-feng, Liu Si, Sun Min   

  1. The 359 Hospital of Chinese PLA, Zhenjiang  212001, Jiangsu Province, China
  • Received:2011-07-25 Revised:2011-10-08 Online:2011-11-19 Published:2011-11-19
  • About author:Wu Zhan-ao, Associate chief physician, The 359 Hospital of Chinese PLA, Zhenjiang 212001, Jiangsu Province, China wuxiaoliang98@ yahoo.com.cn

PDF

390

被引次数

5

摘要：

背景：不同粒径与形貌的纳米羟基磷灰石具有不同的表面特性与生物活性，通过对羟基磷灰石表面进行改性，进而合成出不同粒径的纳米羟基磷灰石，可扩大纳米羟基磷灰石的应用领域。
目的：分析了水热合成法制备羟基磷灰石过程中，实验条件如修饰剂种类、pH值等对羟基磷灰石粒径的影响。
方法：以磷酸与硝酸钙为原料，D-山梨醇、聚丙烯酸钠以及吐温80作为有机修饰剂，不同pH值条件下，水热合成不同粒径的羟基磷灰石。
结果与结论：无修饰剂时，羟基磷灰石的粒径随pH增加迅速降低。聚丙烯酸钠的存在有利于小粒径羟基磷灰石的生成；D-山梨醇的存在有利于较大粒径羟基磷灰石的生成；吐温80的加入在一定程度上降低了羟基磷灰石粒径。

关键词: 水热法, 羟基磷灰石, 有机修饰剂, 粒径, 生物相容性

Abstract:

BACKGROUND: Nanosized hydroxyapatite with different size and morphology has different surface performance and bioactivity. Different sized nanohydroxyapatite was synthesized via surface modification of hydroxyapatite; by this method, the application of nanosized hydroxyapatite can be extended.
OBJECTIVE: To analyze the effect of experimental parameters, such as type of organic modifiers and pH value, etc. on the size of hydroxyapatite synthesized by hydrothermal method.
METHODS: Hydroxyapatite with different sizes was synthesized starting from phosphoric acid and calcium nitrate and using D-sorbitol, sodium polyacrylate and Tween 80 as organic modifiers at different pH values.
RESULTS AND CONCLUSION: In the absence of organic modifier, the size of hydroxyzpatite was decreased rapidly with the increase in pH values. The presence of sodium polyacrylate was beneficial to the formation of small-size hydroxapatite. The addition of D-sorbitol favored the formation of large-size hydroxyapatite. The presence of Tween 80 decreased the size of hydroxyapatite in some extent.

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