中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8792-8796.doi: 10.3969/j.issn.1673-8225.2011.47.013

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

植物性胶黏剂的黏附性及生物相容性

余雪松，黄赤兵，张银甫，范明齐，王平贤，冯嘉瑜，肖  亚   

  1. 解放军第三军医大学新桥医院泌尿外科，重庆市   400037
  • 出版日期:2011-11-19 发布日期:2011-11-19
  • 通讯作者: 黄赤兵，教授，主任医师，解放军第三军医大学新桥医院泌尿外科，重庆市 400037
  • 作者简介:余雪松☆，男，1979年生，湖北省鄂州市人，汉族，解放军第三军医大学在读博士，主要从事移植免疫研究。 yxs197994@ 163.com
  • 基金资助:

    重庆市攻关课题(csci2007AC5046)和全军十一五课题资助项目(2007c118)。

Adhesiveness and biocompatibility of plant adhesive

Yu Xue-song, Huang Chi-bing, Zhang Yin-fu, Fan Ming-qi, Wang Ping-xian, Feng Jia-yu, Xiao Ya   

  1. Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing  400037, China
  • Online:2011-11-19 Published:2011-11-19
  • Contact: Huang Chi-bing, Professor, Chief physician, Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
  • About author:Yu Xue-song☆, Studying for doctorate, Department of Urology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China yxs197994@ 163.com
  • Supported by:

    the Tackle Key Project of Chongqing City, No. csci2007AC5046*; the Funding Project during the Military Eleventh Five-year Plan, No. 2007c118*

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摘要：

背景：前期研究将从植物中提取的原材料加工制备出了一种黏性较强的可吸收性局部止血胶黏剂。
目的：检测局部止血的植物性胶黏剂对肾脏组织的黏附力，并检测其组织相容性。
方法：将不同浓度的植物性胶黏剂均匀涂抹在家兔肾脏表面，检测同一浓度在双侧肾脏不同部位的黏附力。将KM小鼠分为：实验组在大腿肌群切口内填入植物性胶黏剂，对照组切口未加入胶黏剂。
结果与结论：不同浓度的植物性胶黏剂有不同黏附力，1 g植物性胶黏剂粉末中加入0.6 mL蒸馏水组呈较浓糊状，且黏附力高。将胶黏剂埋植入小鼠体内后，皮肤切口愈合良好，实验组和对照组小鼠血生化、免疫学检测差异无显著性意义(P > 0.05)，实验组小鼠手术区肌肉、肝脏和肾脏组织标本苏木精-伊红染色无明显炎症反应。表明植物性胶黏剂有良好的黏附性和组织相容性。

关键词: 止血, 止血材料, 胶黏剂, 黏附力, 组织相容性

Abstract:

BACKGROUND: Previous studies have shown that an absorbable hemostatic adhesive with strong adhesiveness was prepared with raw materials extracted from plants.
OBJECTIVE: To detect the adhesiveness of plant adhesive on kidney and analyze its biocompatibility.
METHODS: The plant adhesive was diluted into different concentration and used on the surface of rabbit kidney. The adhesiveness in the same concentration was recorded. KM mice were divided into experimental group with the plant adhesive and control group without the plant adhesive.
RESULTS AND CONCLUSION: There were different adhesion forces with different concentrations of plant adhesive. When 0.6 mL distilled water was added to 1 g plant adhesive, the mixture had good adhesiveness. The incisions of the mice were well-healed after plant adhesive implantation, and there were no difference in blood biochemistry and immunology examinations between the experiment and control groups (P > 0.05). The histopathological staining of the experiment group did not show any inflammatory reaction in incision muscles, liver and kidney tissues. These findings indicate that the plant adhesive has good adhesiveness and biocompatibility.

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