中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7827-7830.doi: 10.3969/j.issn.1673-8225.2011.42.009

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

一种血液相容性良好的亲水性聚氨酯材料

鲁  金，周慧娟，史惠婷，钱羽锋，贺春丽，梁存霞，李  利   

  1. 南京师范大学，江苏省生物医药功能材料工程研究中心，江苏省南京市  210097
  • 收稿日期:2011-02-17 修回日期:2011-05-09 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 李利，博士，教授，南京师范大学，江苏省生物医药功能材料工程研究中心，江苏省南京市 210097 lili3@njnu.edu.cn
  • 作者简介:鲁金，男，1989年生，江苏省泰兴市人，汉族，南京师范大学高分子化学与物理专业在读学士，主要从事抗凝血生物材料研究。 lujin1989810@ gmail.com
  • 基金资助:

    国家自然科学基金(20874047)“磷铵修饰的聚氨酯生物材料抗凝血机理研究”；江苏省自然科学基金(BK2008434)“生物材料表面高亲水性结构的分子设计及凝血机理研究”；江苏省属高校自然科学研究重大项目(10KJA430026)“生物材料表面亲水性对其血液相容性的影响机制研究”；江苏高校优势学科建设工程资助项目。

A hydrophilic polyurethane material with good blood compatibility

Lu Jin, Zhou Hui-juan, Shi Hui-ting, Qian Yu-feng, He Chun-li, Liang Cun-xia, Li Li   

  1. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing  210097, Jiangsu Province, China
  • Received:2011-02-17 Revised:2011-05-09 Online:2011-10-15 Published:2011-10-15
  • Contact: Li Li, Doctor, Professor, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China lili3@njnu.edu.cn
  • About author:Lu Jin, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China lujin1989810@ gmail.com
  • Supported by:

    the National Natural Science Foundation of China, No. 20874047*; the Natural Science Foundation of Jiangsu Province, No. BK2008434*; the Natural Science Foundation of Jiangsu Provincial Universities, No. 10KJA430026*; Dominant Discipline Construction Project of Jiangsu Provincial Universities*

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摘要：

背景：当聚氨酯材料与活体组织相接触时，会导致一些不良反应，诸如血栓形成和炎症反应。
目的：通过混合亲水性软段来改善聚氨酯材料的亲水性，从而制得抗凝血性能较好的聚氨酯材料。
方法：以聚四氢呋喃、聚乙二醇作为混合软段，4，4’-二苯基甲烷二异氰酸酯为硬段，然后在扩链剂1，4-丁二醇以及催化剂二丁基二月桂酸锡的条件下以预聚法合成一系列聚氨酯材料。
结果与结论：增加聚乙二醇的含量，聚氨酯材料的亲水性提高。软段中含有聚乙二醇的聚氨酯材料依然能够保持聚氨酯材料优良的机械性能，血小板黏附较少，抗凝血性较好。提示通过在聚氨酯合成原料的软段中添加聚乙二醇，可以提高聚氨酯材料的亲水性和血液相容性。

关键词: 聚氨酯, 聚乙二醇, 混合软段, 亲水性, 血液相容性

Abstract:

BACKGROUND: When polyurethane materials are in contact with living organisms, they can cause adverse biological reactions, for example, forming thrombus and inflammation.
OBJECTIVE: To improve the hydrophilicity of polyurethane materials through a mixture of hydrophilic soft segments so as to obtain a polyurethane material with better anticoagulant properties.
METHODS: Polyurethane films were synthesized with polytetrahydrofuran and polyethylene glycol as mixed soft segments,   4, 4’-diphenylmethane diisocyanate as the hard segment, and then in the chain extender 1, 4-butanediol and the catalyst dibutyltin dilaurate conditions to obtain a series of polyurethane materials.
RESULTS AND CONCLUSION: The results showed that hydrophilic and blood compatibility properties of polyurethane films were enhanced, with the increase of the content of polyethylene glycol.

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