中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7045-7048.doi: 10.3969/j.issn.1673-8225.2011.38.004

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

多孔复合掺杂聚磷酸钙支架骨修复材料的制备及其性能

敬起飞2，张  旭1，谢蟪旭3，王启光1，张小华1，余喜讯1，万昌秀1   

  1. 1四川大学高分子科学与工程学院，四川省成都市  610065
    2四川大学材料科学与工程学院，四川省成都市  610065
    3四川大学华西口腔医学院，四川省成都市  610041
  • 收稿日期:2011-05-03 修回日期:2011-06-01 出版日期:2011-09-17 发布日期:2011-09-17
  • 通讯作者: 万昌秀，教授，四川大学高分子科学与工程学院，四川省成都市 610065
  • 作者简介:敬起飞，男，1989年生，四川省南充市人，汉族。
  • 基金资助:

    国家自然科学基金项目(30870614)。

Preparation and properties of porous co-substituted calcium polyphosphate scaffold as bone repair material

Jing Qi-fei2, Zhang Xu1, Xie Hui-xu3, Wang Qi-guang1, Zhang Xiao-hua1, Yu Xi-xun1, Wan Chang-xiu1   

  1. 1College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China
    2College of Materials Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China
    3 West China College of Stomatology，Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-05-03 Revised:2011-06-01 Online:2011-09-17 Published:2011-09-17
  • Contact: Wan Chang-xiu, Professor, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China wanchangxiu@163.com
  • About author:Jing Qi-fei, College of Materials Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China jingqifei525@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30870614*

PDF

420

被引次数

6

摘要：

背景：离子掺杂是生物陶瓷改性的一种重要方法。
目的：评估复合掺杂生物陶瓷作为骨修复材料的可行性。
方法：将钾离子和锶离子复合掺入聚磷酸钙中，制得一种新型骨修复材料—KSCPP。采用扫描电镜和X射线衍射检测分析聚磷酸钙和KSCPP的微观结构和结晶情况；采用抗压强度测试实验、体外降解实验、体外细胞培养实验表征KSCPP的性能，并且进行短期兔肌肉植入实验观察KSCPP的组织相容性。
结果与结论：与羟基磷灰石和聚磷酸钙相比较，KSCPP支架材料拥有更高的抗压强度和更快的降解速度及更低的细胞毒性和更好的组织相容性。

关键词: 复合掺杂, 聚磷酸钙, 降解, 钾离子, 锶离子, 生物相容性

Abstract:

BACKGROUND: Ions doping is an important method for the modification of bioceramic.
OBJECTIVE: To evaluate a novel co-substituted bioceramic scaffolds as bone repair material.
METHODS: The microstructure and crystallization of the scaffolds were detected by scanning electron microscope and X-ray diffraction. Compression strength test, degradation test and cell culture experiment were assumed to evaluate the properties of KSCPP in vitro. After a short period of muscle pouches implantation, the performance of KSCPP in vivo was evaluated.
RESULTS AND CONCLUSION: The results show that KSCPP scaffold has a higher compressive strength and degradation rate. Moreover, the MTT assay and implantation test reveal that the KSCPP scaffold exhibits lower cytotoxicity and better tissue biocompatibility than CPP and HA. The study proved the great potential of KSCPP in bone repair applications.

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