中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (29): 5413-5416.doi: 10.3969/j.issn.1673-8225.2011.29.023

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

医用几丁糖凝胶预防输卵管复通后的粘连

聂桂香   

  1. 广西全州县人民医院妇科，广西壮族自治区全州县 541500
  • 收稿日期:2011-04-23 修回日期:2011-05-18 出版日期:2011-07-16 发布日期:2011-07-16
  • 作者简介:聂桂香，女，1969年生，湖南省衡阳县人，汉族，1992年广西医科大学毕业，主治医师，主要从事妇科疾病和不孕不育诊疗工作。 nq-273487358@126.com

Chitosan gel intervention to prevent adhesions after tubal recanalization

Nie Gui-xiang   

  1. Department of Gynecology, People’s Hospital of Quanzhou County, Quanzhou  541500, Guangxi Zhuang Autonomous Region, China
  • Received:2011-04-23 Revised:2011-05-18 Online:2011-07-16 Published:2011-07-16
  • About author:Nie Gui-xiang, Attending physician, Department of Gynecology, People’s Hospital of Quanzhou County, Quanzhou 541500, Guangxi Zhuang Autonomous Region, China nq-273487358@126.com

PDF

806

被引次数

12

摘要：

背景：近年来随着微创技术的普及，输卵管介入复通治疗输卵管阻塞已较普遍，但患者术后粘连仍是困扰临床医生的一大难题。
目的：总结近年来医用几丁糖凝胶预防输卵管再通术后粘连的应用现状。
方法：由第一作者检索1998-02/2011-02万方数据库，以“医用几丁糖凝胶；腹腔镜；治疗；输卵管妊娠”等为检索词，检索几丁糖在输卵管介入再通术中预防术后粘连方面的文献。排除重复研究或较陈旧文献。共保留相关文献30篇进行分析。
结果与结论：医用几丁糖是一种具有良好生物相容性、生物可降解性、生物学活性的医用高分子多糖类物质。其具有广谱抑菌作用，选择性促进上皮细胞、内皮细胞生长而抑制成纤维细胞生长的生物学特性，从而促进组织生理性修复，促进切口迅速修复，抑制瘢痕形成，减少组织粘连，具有润滑、生物屏障作用，能有效的阻止粘连发生，促进输卵管功能的恢复，为再次妊娠打下基础。

关键词: 医用几丁糖凝胶, 腹腔镜, 治疗, 输卵管妊娠, 生物制剂

Abstract:

BACKGROUND: With the popularity of minimally invasive techniques in recent years, tubal recanalization treatment for tubal obstruction has been more common, but postoperative adhesion is still a great trouble for clinicians.
OBJECTIVE:To review the application status of chitosan gel in the treatment of adhesion following tubal recanalization.
METHODS: The first author retrieved related articles about application of chitosan gel against postoperative adhesion following tubal recanalization published from 1998-02 to 2011-02 using the keywords of “chitosan gel; laparoscopy; treatment; tubal pregnancy”. Repetitive or old articles were excluded, and finally 30 relevant papers were included.
RESULTS AND CONCLUSION: Chitosan is a medical polymer polysaccharide with good biocompatibility, biodegradability and biological activity. With broad-spectrum antimicrobial effect, chitosan selectively promotes the growth of epithelial cells and endothelial cells, and inhibits fibroblast growth, thereby contributing to physiological tissue repair and rapid wound healing, inhibiting scar formation, and reducing tissue adhesion. Because of lubrication and biological barrier effects, chitosan can effectively prevent adhesion occurrence and promote functional recovery of the oviduct to lay the foundation for the subsequent pregnancy.

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