中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4854-4856.doi: 10.3969/j.issn.1673-8225.2011.26.026

• 骨与关节损伤基础实验 basic experiments of bone and joint injury • 上一篇    下一篇

兔胫骨平台骨折愈合中的骨密度变化

王维彬1，韩大成2，张培训2，张洪波2，姜保国2   

  1. 1秦皇岛市第一医院骨科，河北省秦皇岛市 066000
    2北京大学人民医院创伤骨科，北京市  100044
  • 收稿日期:2011-05-18 修回日期:2011-06-14 出版日期:2011-06-25 发布日期:2011-06-25
  • 作者简介:王维彬☆，男，1970年生，河北省文安县人，汉族，2010年北京大学毕业，博士，主治医师，主要从事骨折愈合方面的研究。 wangweibin@bjmu.edu.cn

Bone density changes during tibial plateau fracture healing in rabbits

Wang Wei-bin1, Han Da-cheng2, Zhang Pei-xun2, Zhang Hong-bo2, Jiang Bao-guo2   

  1. 1Department of Orthopaedics, First Hospital of Qinhuangdao, Qinhuangdao  066000, Hebei Province, China
    2Department of Orthopaedics and Traumatology, Peking University People’s Hospital, Beijing 100044, China
  • Received:2011-05-18 Revised:2011-06-14 Online:2011-06-25 Published:2011-06-25
  • About author:Wang Wei-bin☆, Doctor, Attending physician, Department of Orthopaedics, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, China wangweibin @bjmu.edu.cn

PDF

374

被引次数

9

摘要：

背景：目前对胫骨平台骨折的基础研究多集中在生物力学方面，对于其愈合过程中骨密度变化规律的研究很少。
目的：观察胫骨平台骨折愈合过程中的骨密度变化情况。
方法：选择18只新西兰大白兔制作胫骨平台骨折动物模型，骨折复位后用螺钉加压固定，分别于术后1，2，3，4，6，8周取胫骨标本。另取3只正常兔的胫骨标本作为对照。
结果与结论：双能X射线骨密度测量显示，术后1周骨密度值较对照组略有降低，2周时骨密度值明显增大且差异显著(P < 0.05)。3周时骨密度值陡然降低，3，4，6周时测得的骨密度值总体差异不大，4周时略为增高，8周时骨密度值又略微降低，3，4，6，8周数据比较差异无显著性意义。提示在良好的复位固定条件下，术后2周时骨折区域的骨密度值最高、成骨作用最强。

关键词: 胫骨骨折, 骨折固定术, 内, 骨折愈合, 骨密度, 兔, 截骨术

Abstract:

BACKGROUND: Though the tibial plateau fractures are common in clinic, the studies on the fracture healing mostly focus on the treatment, and the change of bone density in the healing process is seldom concerned.
OBJECTIVE: To evaluate the bone density changes in the healing process of tibial plateau fractures in rabbits.
METHODS: All experiments were performed on 18 New Zealand rabbits. The tibial plateau fractures were created by oblique osteotomy, reduced, and then fixed by screws. At selected time points after operation (1, 2, 3, 4, 6, and 8 weeks), the tibial specimens were harvested and the bone density of fracture zone was measured with a dual energy x-ray absorptiometry scanner (DEXA). Intact tibia specimens of three rabbits were measured as controls.
RESULTS AND CONCLUSION: The bone mineral density of the fracture aera declined slightly in the first week after fracture compared with the control group. It rose significantly in the second week postoperatively and descended vigorously from the third week. Then the value of bone mineral density varied slightly, except a little high relatively in the fourth week and a little low in the eighth week. From the changes of bone density in the healing process, it showed that the bone mineral density and bone formation reached the peak at 2 weeks after fracture under the good reduction and fixation.

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