中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (26): 4813-4816.doi: 10.3969/j.issn.1673-8225.2011.26.016

• 骨与关节循证医学 evidence-based medicine of the bone and joint • 上一篇    下一篇

中药熏洗辅助关节镜清理治疗膝骨关节炎的Meta分析

钱定军1，成  昊2，向一鸣1   

  1. 1咸宁学院附属第二医院骨科，湖北省咸宁市   437100
    2武汉大学中南医院骨科，湖北省武汉市   430071
  • 收稿日期:2011-03-04 修回日期:2011-05-11 出版日期:2011-06-25 发布日期:2011-06-25
  • 作者简介:钱定军，男，1976年生，湖北省咸宁市人，汉族，2004年咸宁学院毕业，主治医师，主要从事骨外科常见病的诊治研究。 qiandingjun123@163.com

Chinese herbs-aided arthroscopic surgery for knee osteoarthritis: A Meta-analysis

Qian Ding-jun1, Cheng Hao2, Xiang Yi-ming1   

  1. 1Department of Orthopedics, the Second Affiliated Hospital of Xianning University, Xianning  437100, Hubei Province, China
    2Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan  430072, Hubei Province, China
  • Received:2011-03-04 Revised:2011-05-11 Online:2011-06-25 Published:2011-06-25
  • About author:Qian Ding-jun, Attending physician, Department of Orthopedics, the Second Affiliated Hospital of Xianning University, Xianning 437100, Hubei Province, China qiandingjun123@163.com

PDF

334

被引次数

10

摘要：

背景：目前国内出现了许多用中药辅助关节镜清理技术治疗膝骨关节炎的临床研究，但其疗效是否要优于单用关节镜技术，尚缺乏相关的循证医学证据。
目的：评估中药辅助关节镜清理技术治疗膝骨关节炎的效果。
方法：通过计算机和手工系统检索Cochrane图书馆(2010年第4期)、Medline、CBM、VIP、CNKI和WANFANG DATA(均为建库至2010-12)，纳入比较关节镜技术单用(或与医药联用)和与中药联用治疗膝骨关节炎疗效的临床随机对照试验，两人独立评价其方法学质量后采用RevMan5.0软件进行Meta分析。
结果与结论：最终纳入11个临床随机对照试验，共1 304个膝关节，方法学质量多为B级。Meta分析结果从整体上显示，采用中药辅助关节镜清理技术治疗膝骨关节炎的效果优于单独采用关节镜清理技术或采用西药辅助。上述文献均未报道不良事件，且方法学质量不高，故建议进行严格设计、大样本、随机双盲对照试验来进一步证实。

关键词: 骨关节炎, 膝关节, 中药, 关节镜清理技术, Meta分析

Abstract:

BACKGROUND: Since the ancient times the fumigation washing therapy with Chinese herbs are used to treat patients of knee osteoarthritis (KOA), nowadays domestic appeared many studies with Chinese herbs-aided arthroscopic surgery to treat KOA, but if the effectiveness is better than arthroscopic surgery alone, it is still lack of evidence.
OBJECTIVE: To evaluate whether the Chinese herbs-aided arthroscopic surgery is superior to arthroscopic surgery alone, and in order to provide some references for rational treatment in the clinic.
METHODS: A computer-based online search of Cochrane Library (Issue 1, 2010), Medline, CBM, VIP, CNKI and WANFANG DATA (from the data base building to the December, 2010) for the clinical randomized controlled trials of arthroscopic surgery alone and Chinese herbs-aided to treating KOA. Hand searching was also done to obtain any further information about the studies. After study selection, data collection, assessment and analyses were undertaken by two reviewers independently, and heterogeneous studies, we performed meta-analysis using RevMan 5.0 software.
RESULTS AND CONCLUSION: Eleven studies involving 1 304 knee joint were included, and the level of quality of most studies were B. Meta-analysis indicated that the effectiveness of Chinese herbs-aided arthroscopic surgery is superior to alone (or combined with Western drugs), but there are no studies concerning relative dose and side effect. So we suggest the researchers to perform studies in this kind which should obey the unity of the evaluation standard design multicenter, large sample, double-blind controlled studies in order to support the results.

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