中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (21): 3913-3916.doi: 10.3969/j.issn.1673-8225.2011.21.026

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

高分子材料聚乙烯膜型血浆分离器用于高脂血症35例

于  颖，孟建中，景  颖，王素霞，葛彦明，贾凤玉   

  1. 解放军济南军区总医院血液净化中心，山东省济南市  250031
  • 收稿日期:2010-11-13 修回日期:2010-12-30 出版日期:2011-05-21 发布日期:2011-05-21
  • 作者简介:于颖，女 1961年生，山东省荣成市人，汉族，2001年解放军第四军医大学毕业，副主任护师，主要从事血液净化研究。 YUY2009@126.com

Polymer polyethylene membrane plasma separator in hyperlipemia: A 35-case analysis

Yu Ying, Meng Jian-zhong, Jing Ying, Wang Su-xia, Ge Yan-ming, Jia Feng-yu   

  1. Blood Purification Center, General Hospital of Jinan Military Area Command of Chinese PLA, Jinan   250031, Shandong Province, China
  • Received:2010-11-13 Revised:2010-12-30 Online:2011-05-21 Published:2011-05-21
  • About author:Yu Ying, Associate chief superintendent nurse, Blood Purification Center, General Hospital of Jinan Military Area Command of Chinese PLA, Jinan 250031, Shandong Province, China YUY2009@126.com

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摘要：

背景：血脂清洗新技术通过双重滤过血浆置换，能有效降低50%~70%的胆固醇、三酰甘油、低密度脂蛋白、脂蛋白、纤维蛋白原，而不影响血浆的其他成分如白蛋白、球蛋白、免疫蛋白、电解质等。
目的：观察聚乙烯膜型血浆分离器和模式血浆成分分离器治疗高脂血症的效果。
方法：对35例高血脂患者实施聚乙烯膜型血浆分离器和模式血浆成分分离器行血脂清洗治疗，血脂清洗机的操作，抗凝剂量使用，血液及免疫观察指标均按操作规程和相应监测数据进行。
结果与结论：35例患者治疗后大部分血脂下降明显，血液黏稠度降低，普遍反映因高血脂引发的嗜睡、失眠、精力不集中等临床症状明显好转，原有的糖尿病、高血压、冠心病也较容易控制，其中有5例冠心病常伴有发作性胸痛、胸闷者，经血脂清洗后未再发作。伴有糖尿病的9例经血脂清洗治疗后血糖也得到控制。说明采用聚乙烯膜型血浆分离器和模式血浆成分分离器血脂清洗治疗高血脂症临床效果确切，大样本实验有待进一步验证。

关键词: 血脂清洗, 聚乙烯, 模式血浆成分离器, 高脂血, 临床

Abstract:

BACKGROUND: Blood lipid cleaning (BLC) can effectively reduce 50-70% of the level of cholesterol (CH), glycerin trilaurate (TG), low density lipoprotein (LDL), lipoprotein (a) and fibrinogen by double filtration plasmapheresis, without affecting the other components of plasma such as albumin, globulin, immune proteins, and electrolytes.
OBJECTIVE: To observe the effect of polyethylene membrane plasma separator and membrane plasma separator in the treatment of hyperlipidemia.
METHODS: A total of 35 cases of patiants with hyperlipemia were treated by BLC with polyethylene membrane plasma separator and membrane plasma separator. The operation of BLC machine, the use of anticoagulant dosage, blood, and immune outcome measures were performed according to operation procedure and corresponding monitoring data.
RESULTS AND CONCLUSION: The level of blood-fat was significantly reduced and the blood viscidity was lowered in 35 cases after treatment. The clinical symptoms such as drowsiness, insomnia, unfocused were visibly improved. Existing diabetes, hypertension and coronary disease were more easily controlled, including 5 cases of coronary heart disease was often accompanied by episodes of chest pain and chest tightness, and free of recurrence by BLC. Glucose was controlled preferably in 9 cases of diabetes after the treatment of BLC. It is indicated that the clinical effect of BLC with polyethylene membrane plasma separator and membrane plasma separator in the treatment of hyperlipemia was reliable, large sample test needs to be further verified.

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