中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (11): 2059-2063.doi: 10.3969/j.issn.1673-8225.2011.11.040

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

胚胎发育与环境激素的影响

胡梦桑，陈毅斐，徐  营   

  1. 嘉兴学院医学院，浙江省嘉兴市 314001
  • 收稿日期:2010-10-10 修回日期:2010-12-02 出版日期:2011-03-12 发布日期:2011-03-12
  • 通讯作者: 徐营，博士，副教授，嘉兴学院医学院，浙江省嘉兴市 314001 Xuyingmrd@ yahoo.com
  • 作者简介:胡梦桑，女，1989年生，浙江省宁波市人，嘉兴学院医学院本科在读，主要从事临床医学方面的研究。 418828171@qq.com
  • 基金资助:

    浙江省实验动物平台计划项目(2008F80025)、嘉兴市科研项目(2010AY1098)和浙江省大学生科技创新活动计划(新苗人才计划)项目(851910104)资助。

Effects of environmental hormone on embryonic development

Hu Meng-sang, Chen Yi-fei, Xu Ying   

  1. Medical College of Jiaxing University, Jiaxing  314001, Zhejiang Province, China
  • Received:2010-10-10 Revised:2010-12-02 Online:2011-03-12 Published:2011-03-12
  • Contact: Xu Ying, Doctor, Associate professor, Medical College of Jiaxing University, Jiaxing 314001, Zhejiang Province, China Xuyingmrd@yahoo. com
  • About author:Hu Meng-sang, Medical College of Jiaxing University, Jiaxing 314001, Zhejiang Province, China 418828171@qq.com
  • Supported by:

    the Experimental Animal Platform Plan of Zhejiang Province, No. 2008F80025*; the Science and Technology Program of Jiaxing City, No. 2010AY1098*; the Science and Technology Innovation Plan for University Students of Zhejiang Province, No. 851910104* 

PDF

694

被引次数

20

摘要：

背景：自然环境中胚胎发育异常，性行为异常，生物两性化以及种族繁殖数量减少等现象的发生概率升高与环境激素有关。随着环境污染的日趋加重，环境激素对胚胎发育的影响已日益受到重视。
目的：分析环境激素对早期胚胎着床、着床前期早期胚胎发育及其对胚胎期胚胎的生殖系统发育的影响及其机制。
方法：使用环境激素及己烯雌酚、米非司酮、甲氧滴滴涕、胚胎发育、胚胎早期发育等关键词，检索中国知识资源总库与PubMed数据库中的相关研究论文，分析环境激素对不同时期胚胎发育的影响。
结果与结论：纳入45篇符合标准的文献。环境激素广泛存在于日常生活中，种类繁多，作用机制复杂多样，且不同环境激素之间可能还存在协同作用，对分子水平的机制探索还处于初级阶段。控制环境激素生成源，尽量减少人为排放是降低环境激素对人类健康影响的重要措施。

关键词: 环境激素, 己烯雌酚, 米非司酮, 甲氧滴滴涕, 双酚A, 早期胚胎发育, 着床

Abstract:

BACKGROUND: Many studies have shown that the increasing occurrence of reproductive abnormalities in wild life may be associated with exposure to environmental hormone. With the pollution of the environment, effects of environmental hormone on embryonic development have been paid more and more attention.
OBJECTIVE: To review the effects and possible mechanism of various environmental hormone on the process of embryo implantation, embryonic development during preimplantation and the development of embryonic reproductive system.
METHODS: CNKI database and Pubmed database were searched using key words of “environmental hormone and diethylstilbestrol, mifepristone, methoxychlor, bisphenol A, tetrachlorodibenzo-p-dioxin, embryonic development, early embryonic development”, for papers addressing the effects of environmental hormone on embryonic development.
RESULTS AND CONCLUSION: Totally 45 articles were adapted. Common environmental hormones widely spread in daily life in a great variety. Different environmental hormones have synergistic reaction. The mechanism exploration is at the step stage. It is necessary to control production source of environmental hormones and reduce anthropogenic discharge to decline the effect of environmental hormones on human healthy. 

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