中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (3): 507-510.doi: 10.3969/j.issn.1673-8225.2011.03.031

• 生物材料综述 biomaterial review • 上一篇    下一篇

聚乳酸降解材料的绿色化学合成

许文殊1，罗祥林1, 2   

  1. 四川大学，1高分子科学与工程学院， 2高分子国家重点实验室，四川省成都市  610065
  • 收稿日期:2010-06-25 修回日期:2010-08-30 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 罗祥林，博士，博士生导师，四川大学高分子科学与工程学院；高分子国家重点实验室，四川省成都市 610065 luoxl_scu@126.com
  • 作者简介:许文殊★，男，1983年生，黑龙江省齐齐哈尔市人，汉族，四川大学高分子科学与工程学院在读硕士，主要从事生物降解材料的研究。 xuwenshu2003@163.com
  • 基金资助:

    国家自然科学基金(50873065)资助项目。

Green chemical synthesis of poly(lactic acid) based biodegradable polymers

Xu Wen-shu1, Luo Xiang-lin1,2   

  1. 1College of Polymer Science and Engineering, 2State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu   610065, Sichuan Province, China
  • Received:2010-06-25 Revised:2010-08-30 Online:2011-01-15 Published:2011-01-15
  • Contact: Luo Xiang-lin, Doctor, Doctoral supervisor, 1College of Polymer Science and Engineering, 2State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China luoxl_scu@126.com
  • About author:Xu Wen-shu★, Studying for master’s degree, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, Sichuan Province, China xuwenshu2003@163.com
  • Supported by:

    the National Natural Science Foundation of China, No.50873065*

PDF

755

被引次数

12

摘要：

背景：聚乳酸具有良好的生物相容性和生物降解性，广泛应用于药物缓释、手术缝合线、组织工程支架及骨修复材料等生物医用领域。但其常规合成方法需使用溶剂，生产效率较低且成本较高。
目的：对非溶剂的绿色化学方法-乳酸熔融缩聚/二异氰酸酯熔融扩链，合成聚乳酸降解材料的研究进展进行综述。
方法：应用计算机检索SCI-Expanded数据库(1995-01/2010-06)，以“Poly(lactic acid)，diisocyanate”为检索词；应用计算机检索中国期刊网络出版总库(1999-01/2010-06)，以“聚乳酸，异氰酸酯”为检索词。共收集130篇关于乳酸熔融缩聚/二异氰酸酯熔融扩链的文献，中文39篇，英文91篇。排除发表内容重复、实验结果较差的文献，共32篇文献符合标准被纳入。
结果与结论：采用非溶剂的绿色化学方法-乳酸熔融缩聚/二异氰酸酯熔融扩链，通过改变异氰酸酯和预聚物的种类和比例，就可以制备具有不同相对分子质量和性能的可降解聚乳酸基聚氨酯材料，有望在生物医用领域和日常生活中取得实际的应用。

关键词: 熔融缩聚, 熔融扩链, 降解材料, 聚乳酸, 异氰酸酯

Abstract:

BACKGROUND: Poly(lactic acid) has excellent biocompatibility and biodegradability, thus it has been widely used in many biomedical fields, such as drug delayed release, surgical suture, tissue engineering scaffold and bone substitutes. Routine synthesis requires the use of solvent, showing low production efficacy and high cost.
OBJECTIVE: Non-solvent green chemical synthesis of poly(lactic acid) based biodegradable materials via direct condensation polymerization and chain extension in melt state were reviewed.
METHODS: A computer-based online search of SCI-Expanded database (1995-01/2010-06) and China Academic Journal Network Publishing Database was performed for related articles with the key words of “poly (lactic acid), diisocyanate” in English and in Chinese. A total of 130 articles regarding the lactic acid polycondensation/diisocyanate chain extension in melt state, including 39 Chinese papers and 91 English ones. Articles with duplicated content and poor experimental results were eliminated, finally 32 articles met the criteria were included.
RESULTS AND CONCLUSION: The biodegradable polylactic acid-based polyurethane materials with different molecular weights and properties can be prepared by lactic acid melt polycondensation/diisocyanate melt chain extension with green chemical method using non-solvent, through changing the type and proportion of isocyanates and prepolymers, it is expected to be practically applied in biomedical fields and daily life.

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