中国组织工程研究

中国组织工程研究

• 生物材料综述 biomaterial review • 上一篇    下一篇

纳米银抗菌技术在临床医疗中的应用

何  伟1，2，张发明1，2，3，范志宁1，2，3   

  1. 南京医科大学第二附属医院，1消化医学中心，2消化内镜研究所，3转化医学研究所，江苏省南京市  2100292
  • 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 范志宁，博士生导师，主任医师，南京医科大学第二附属医院消化内镜中心。 fanzhining@hotmail.com
  • 作者简介:何伟★，女，1985年生，江苏省常州市人，汉族，南京医科大学在读硕士，主要从事消化微创外科方面的研究。 bingbing_he@yeah.net
  • 基金资助:

    本项目受国家高技术研究发展计划（863计划）（2007AA02190）资助。

Application of nano-silver antibacterial technology in clinical healthcare

He Wei 1,2, Zhang Fa-ming 1,2,3, Fan Zhi-ning 1,2,3   

  1. 1 Medical Center for Digestive Diseases, 2 Institute of Digestive Endoscopy, 3 Translational Medicine Institute, Second Affiliated Hospital of Nanjing Medical University, Nanjing   210029, Jiangsu Province, China
  • Online:2010-10-15 Published:2010-10-15
  • Contact: Fan Zhining, Doctoral supervisor, Chief physician, 1Medical Center for Digestive Diseases, 2Institute of Digestive Endoscopy, 3Translational Medicine Institute, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China fanzhining@hotmail.com
  • About author:He Wei★, Studying for master’s degree, 1Medical Center for Digestive Diseases, 2Institute of Digestive Endoscopy, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China bingbing_he@yeah.net
  • Supported by:

    the National High-Tech Research & Development Program of China (863 Program), No. 2007AA02190*

PDF

1535

被引次数

44

摘要：

背景：作为一种新型无机抗菌材料，纳米银不仅具备超强的抗菌效果，且对人体更为安全。
目的：就纳米银材料的结构特性和抗菌机制、生物安全性、在医疗卫生领域的应用以及未来发展方向作一概述，以期纳米银材料得到广泛和有效的应用。
方法：应用计算机检索PubMed数据库中1997-01/2010-03关于纳米银抗菌机制及生物安全性的文章，在标题和摘要中以“nanosilver;antibacteria;biofilm;bio-safty”为检索词进行检索，选择文章内容与纳米银抗菌机制、细菌生物膜、以及纳米银生物安全性相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检共得到123篇文献，根据纳入标准选择42篇文章进行综述。
结果与结论：纳米银材料由于其量子效应、小尺寸效应和极大的比表面积特性，容易与病原微生物密切接触，从而发挥更大的生物效应，因此具有抗菌范围广、持续杀菌时间长等优点。其抗菌广谱抗菌作用机制的深入，将为研制安全有效的广谱抗菌的纳米抗菌药物和材料提供理论基础和实验依据，为人类细菌感染的广谱预防和治疗提供新的方法和策略。

关键词: 纳米银, 抗菌, 生物膜, 生物安全性, 医疗应用

Abstract:

BACKGROUND: As a new type of inorganic antibacterial materials, nano-silver has strong antibacterial effect and safety on human body.
OBJECTIVE: To summarize the structural properties, antimbacterial mechanisms, bio-safety, medical applications and further development of nano-silver, and to explore extensive and effective application of nano-silver materials.
METHODS: Articles about antibacterial mechanism and bio-safety of nanosilver were retrieved from PubMed database with the key words of “nanosilver; antibacteria; biofilm; bio-safety” from January 1997 to March 2010. articles related to antibacterial effect and bio-safety of nanosilver, as well as bacterial biofilm were included, those published in the authoritative journals or recently published were preferred in the same field. After primary screen, 123 articles were retrieved, 42 of them in accordance with inclusive criteria were included in the final analysis.
RESULTS AND CONCLUSION: The nano-silver materials are prone to contact with pathogenic microorganism due to quantum effect, small size effect and great specific surface area, therefore displaying more biologic effect and more disadvantages such as wide antibacterial range and long disinfection time. Further research on the broad-spectrum antibacterial mechanism of nanosilver would provide a theoretical and experimental basis for the development of safe, reliable, broad-spectrum antibacterial nano-materials and nano-drugs, can open up new ways of bacterial infection treatment prevention and treatment for the mankinds.

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