中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (19): 3578-3580.doi: 10.3969/j.issn.1673-8225.2010.19.033

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

表皮干细胞的研究进展

谢一帆，吴 岩   

  1. 内蒙古医学院组织胚胎学教研室，内蒙古自治区呼和浩特市 010059
  • 出版日期:2010-05-07 发布日期:2010-05-07
  • 通讯作者: 吴 岩，教授，博士，硕士生导师，内蒙古医学院组织胚胎学教研室，内蒙古自治区呼和浩特市 010059 yanw007@sina.com
  • 作者简介:谢一帆，女，1981年生，河北省石家庄市人，汉族，内蒙古医学院在读硕士，主要从事干细胞发生方面的研究。 yfxie11@126.com
  • 基金资助:

    省部高校共建专项基金([2005]1162)

Research progress in epidermal stem cells

Xie Yi-fan, Wu Yan   

  1. Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China
  • Online:2010-05-07 Published:2010-05-07
  • Contact: Wu Yan, Professor, Doctor, Master’s supervisor, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China yanw007@sina.com
  • About author:Xie Yi-fan, Studying for master’s degree, Department of Histology and Embryology, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China yfxie11@126.com
  • Supported by:

    Provincial and Departmental  Special Foundation for Higher Eduction Institute, No. [2005]1162*

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摘要：

背景：随着分子生物学、细胞生物学及生物工程学的发展，表皮干细胞凭借其特有的生物学优势在基因治疗、细胞治疗中越来越受到重视。
目的：综述表皮干细胞的相关研究进展。
方法：第一作者应用计算机检索2000-01/2009-01 PubMed数据库(网址http://www.ncbi.nlm.nih.gov/PubMed)相关文章，检索词为“epidermal stem cell，marker，clinical application”，并限定文章语言种类为English。同时计算机检索2000-01/2009-01 CNKI数据库(网址http://www.cnki.net/index.htm)相关文章，检索词为“表皮干细胞，标记物，临床应用”，并限定文章语言种类为中文。共检索到文献815篇，最终纳入21篇。
结果与结论：了解表皮干细胞的来源、分布特征、鉴定方法、增殖与分化调控的机制、临床应用现状等方面的研究进展是进一步应用表皮干细胞治疗疾病的重要前提和理论基础。表皮干细胞具有无限增殖和多向分化的潜能，对维持表皮的自我更新、保持皮肤的正常结构以及对皮肤的创伤修复具有重要意义。表皮干细胞已引起越来越多研究者的关注。

关键词: 表皮干细胞, 标记物, 临床应用, 综述文献

Abstract:

BACKGROUND: Epidermal stem cells have been paid great attention on the research of gene therapy and cell therapy with its specific biological advantages with the development of molecular biology, cell biology and bioengineering.
OBJECTIVE: To summarize relative research progress of epidermal stem cells.
METHODS: The first author retrieved PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) for English articles published from January 2000 to January 2009. The key words were “epidermal stem cell, marker, clinical application”. Simultaneously, CNKI database (http://www.cnki.net/index.htm) was also retrieved for relevant Chinese articles published from January 2000 to January 2009. The key words were “epidermal stem cell, marker, clinical application”. A total of 815 articles were obtained, and finally 21 articles were included.
RESULTS AND CONCLUSION: To understand the research progress of source, distribution characteristics, identification method, proliferation, differentiation and regulation mechanisms, present clinical application of epidermal stem cells is the major premise and theoretical basis of epidermal stem cells for treating diseases. Epidermal stem cells have the potential of proliferation and multi-directional differentiation, and have important significances for maintaining epidermal self-renewal, keeping normal structure and repairing skin trauma. Epidermal stem cells have attracted more and more interest of researchers.

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