中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (19): 3569-3572.doi: 10.3969/j.issn.1673-8225.2010.19.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

内皮祖细胞与缺血性脑卒中

李欢欢1，何 旭2，刘亢丁1   

  1. 1吉林大学第一医院神经内科，吉林省长春市130021
    2吉林大学白求恩医学院病理生物学教育部重点实验室病理教研室，吉林省长春市130021
  • 出版日期:2010-05-07 发布日期:2010-05-07
  • 通讯作者: 刘亢丁，博士研究生导师，主任医师，吉林大学第一医院神经内科，吉林省长春市 130021 kangdingliu＠163.com
  • 作者简介:李欢欢，女，1984年生，河南省灵宝市人，汉族，吉林大学第一医院神经内科在读硕士，医师，主要从事脑血管疾病的研究， huanhuan19840620＠163.com
  • 基金资助:

    国家自然科学基金项目(30770755)

Endothelial progenitor cells and ischemic stroke

Li Huan-huan1, He Xu2, Liu Kang-ding1   

  1. 1Department of Neurology, First Hospital, Jilin University, Changchun   130021, Jilin Province, China;
    2Department of Pathology, Key Laboratory of Pathobiology of Ministry of Education, Norman Bathune College of Medicine, Jilin University, Changchun  130021, Jilin Province, China
  • Online:2010-05-07 Published:2010-05-07
  • Contact: Liu Kang-ding, Doctoral supervisor, Chief physician, Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China kangdingliu@163.com
  • About author:Li Huan-huan, Studying for master’s degree, Physician, Department of Neurology, First Hospital, Jilin University, Changchun 130021, Jilin Province, China huanhuan19840620＠163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30770755*

PDF

540

被引次数

13

摘要：

背景：内皮祖细胞不仅能够早期预测血管损伤的程度，而且具有修复损伤的内皮细胞、促进新生血管形成管腔结构、参与神经再生的功能。内皮细胞移植已逐渐应用于血管相关性疾病的治疗。
目的：文章综述了内皮祖细胞的生物学特性及在缺血性脑卒中领域的最新研究进展，为其临床应用提供理论支持。
方法：以“endothelial progenitor cells； ischemic infarction；”为检索词检索Medline、HighWire Press数据库(2000-01/2009-12)。纳入与血管新生、内皮和神经再生密切相关的研究，排除内容陈旧、重复性及缺乏可信度文章。
结果与结论：计算机初检得到126篇文献，根据纳入排除标准，对其中28篇文献进行分析。内皮祖细胞具有修复损伤的内皮细胞、延缓动脉粥样硬化进展、促进缺血组织新生血管形成等功能，它参与缺血性脑卒中后血管新生，防治支架术后血栓形成及再狭窄，预测脑缺血的发生及预后，在防治缺血性脑卒中方面具有广泛的应用前景。

关键词: 内皮祖细胞, 缺血性脑卒中, 血管新生, 内皮再生, 神经再生, 综述文献

Abstract:

BACKGROUND: Endothelial progenitor cells not only predict the degree of vascular injury in early stage, but also repair damaged endothelial cells, promote lumen structure formation of new vessels and participate in neural regeneration. Endothelial cell transplantation has been widely applied in treatment of vessel-related diseases.
OBJECTIVE: To summarize biological characteristics and latest research advancement of endothelial progenitor cells in the field of cerebral ischemic stroke, so as to provide theoretical support for its clinical application.
METHODS: We retrieved Medline and HighWire Press databases with the key words of “endothelial progenitor cells, ischemic infarction” for articles published from January 2000 to December 2009. Inclusion criteria: research closely related to angiogenesis, endothelium and neural regeneration. Exclusion criteria: obsolete, repetitive articles and those lack of credibility.
RESULTS AND CONCLUSION: Totally 126 literatures were screened out by computer, according to inclusion and exclusion criteria, 28 documents of which were involved in the analysis. Endothelial progenitor cells can repair damaged endothelium, attenuate the development of atherosclerosis and promote new vessels formation in ischemic tissue. Endothelial progenitor cells participate in angiogenesis after ischemic stroke, fight against stent thrombosis and restenosis, predict the development and prognosis of cerebral ischemia, and have a wide range of application prospects in the treatment of cerebral ischemic stroke.

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