中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (19): 3565-3568.doi: 10.3969/j.issn.1673-8225.2010.19.030

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

间充质干细胞与肿瘤生长发展关系的研究现状

刘 晗1，陈 军2，徐祗顺2   

  1. 1山东大学医学院2006级临床医学五年制三班，山东省济南市  250012；
    2山东大学齐鲁医院泌尿外科，山东省济南市  250012
  • 出版日期:2010-05-07 发布日期:2010-05-07
  • 作者简介:刘 晗，女，1988年生，山东省临沂市人，汉族，山东大学医学院临床医学本科在读。 daerdong@hotmail.com

Relationship of mesenchymal stem cells with tumor growth and development

Liu Han1, Chen Jun2, Xu Zhi-shun2   

  1. 1Five-Year-Course Class Three, Grade 2006 Clinical Medicine Department, Medical College, Shandong University, Jinan  250012, Shandong Province, China;
    2Department of Urinary Surgery, Qilu Hospital, Shandong University, Jinan  250012, Shandong Province, China
  • Online:2010-05-07 Published:2010-05-07
  • About author:Liu Han, Five-Year-Course Class Three, Grade 2006 Clinical Medicine Department, Medical College, Shandong University, Jinan 250012, Shandong Province, China

PDF

426

被引次数

6

摘要：

背景：间充质干细胞是具有多向分化潜能的一类组织干细胞，肿瘤可以诱导间充质干细胞迁移进入肿瘤组织。针对间充质干细胞对肿瘤生长发展的影响目前已经进行了大量的研究。
目的：综述间充质干细胞在肿瘤生长发展过程中的作用。
方法：应用计算机检索2000-01/2009-06 PubMed数据库(网址http://www.ncbi.nlm.nih.gov/PubMed)相关文章，检索词为“mesenchymal stem cell，myofibroblast，neoplasms”，并限定文章语言种类为English。共检索到文献8 372篇，37篇文献符合纳入标准。
结果与结论：间充质干细胞能够迁移进入肿瘤组织并且可以促进肿瘤的生长发展，这一过程可能与间充质干细胞促进肿瘤间质重构、促进肿瘤血管形成、抑制肿瘤局部机体免疫相关。但是也有一些研究结果表明间充质干细胞可以抑制肿瘤生长。因此进一步加深间充质干细胞与肿瘤关系的研究可能会增加人们对肿瘤发病机制的理解。

关键词: 间充质干细胞, 肌纤维母细胞, 肿瘤, 发病机制, 综述文献

Abstract:

BACKGROUND: Mesenchymal stem cells are the cells with the potential of multiple-directional differentiation. Tumor can induce migration of mesenchymal stem cells into tumor tissue. There are many studies concerning the influence of mesechymal stem cells on tumor growth and development.
OBJECTIVE: To review the influence of mesechymal stem cells on tumor growth and development.
METHODS: The PubMed database(http://www.ncbi.nlm.nih.gov/PubMed) (2000-01/2009-06) was searched online. The key words were “mesenchymal stem cell, myofibroblast, neoplasms”. The language was limited as English. Totally 8 372 papers were included. Finally, 37 articles were accorded with inclusion criteria.
RESULTS AND CONCLUSION: Mesenchymal stem cells can migrate into tumor tissue and accelerate tumor development under the induction of tumor tissue, which may be related to the influence of mesenchymal stem cells on tumor stroma remodeling, local immune status and vascular formation. However, some studies have suggested that mesenchymal stem cells suppress tumor growth. Therefore, further studies addressing the relationship between mesenchymal stem cells and tumor development are necessary, which may strengthen our recognition to the mechanism of tumor development.

中图分类号: