中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (12): 2205-2208.doi: 10.3969/j.issn.1673-8225.2010.12.029

• 生物材料综述 biomaterial review • 上一篇    下一篇

细菌生物膜耐药机制的研究与进展

陈铁柱1,2,李晓声1,曾文魁1,2,杜  尧1,2,谭财福1,2   

  1. 1湖南省人民医院骨科,湖南省长沙市  410005;2南华大学,湖南省衡阳市  421001
  • 出版日期:2010-03-19 发布日期:2010-03-19
  • 通讯作者: 李晓声,博士,主任医师,湖南省人民医院骨科,湖南省长沙市 410005 lxsld@sina.com
  • 作者简介:陈铁柱★,男,1983年生,湖南省邵阳市人,汉族,南华大学在读硕士,主要从事骨与关节损伤、关节镜、微创显微外科研究。 ctzmz11@163.com

Research and progress of drug-resistant mechanism of bacterial biofilm

Chen Tie-zhu 1, 2, Li Xiao-sheng1, Zeng Wen-kui 1, 2, Du Yao 1, 2,Tan Cai-fu 1, 2   

  1. 1 Department of Orthopaedics, Hunan Provincial People’s Hospital, Changsha  410005, Hunan Province, China; 2 Nanhua University, Hengyang   421001, Hunan Province, China
  • Online:2010-03-19 Published:2010-03-19
  • Contact: Li Xiao-sheng, Doctor, Chief physician, Department of Orthopaedics, Hunan Provincial People’s Hospital, Changsha 410005, Hunan Province, China lxsld@sina.com
  • About author:Chen Tie-zhu★, Studying for master’s degree, Department of Orthopaedics, Hunan Provincial People’s Hospital, Changsha 410005, Hunan Province, China; Nanhua University, Hengyang 421001, Hunan Province, China ctzmz11@163.com

摘要:

背景:细菌形成生物膜后耐药性极强,可以逃避宿主的免疫作用,在感染部位难以彻底清除,是临床上难治性感染的重要原因之一。
目的:文章综述了细菌生物膜耐药机制的研究进展,以便寻找有效控制手段,指导临床合理用药和新药开发。
方法:应用计算机检索CNKI和PubMed数据库中1998-01/2008-12关于细菌生物膜耐药机制的文章,在标题和摘要中以“生物膜;耐药性;细菌;感染”或“biofilm; Drug resistance; bacteria; Infection”为检索词进行检索。选择文章内容与细菌生物膜感染相关,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到285篇文献,根据纳入标准选择23篇文章进行综述。
结果与结论:对细菌生物膜形成机制的了解,有利于更合理选择抗生素,有效的控制好临床感染。细菌形成生物膜后耐药性明显增加,耐药机制尚未完全清楚,生物膜的ESS物理屏障作用、特殊微环境、细菌密度感应系统等在耐药形成中都发挥一定作用,而且可能是多因素协同作用。通过该方面的机制研究指导临床用药和新药开发。

关键词: 生物膜, 耐药性, 细菌, 感染, 生物材料, 综述文献

Abstract:

BACKGROUND: After the formation of biofilm, drug resistance of bacteria was strong, and it could evade the host immune function and be difficultly eradicated at the site of infection. Therefore, it was one of important reasons of refractory infection in clinic.
OBJECTIVE: To review the research and progress of drug-resistant mechanisms of bacterial biofilm in order to find effective means and guide clinical use of drugs and drug discovery.
METHODS: Articles about drug-resistant mechanism of bacterial biofilm were retrieved from CNKI and PubMed with the key words of “iofilm; drug resistance; bacteria; infection” in both Chinese and English from January 1998 and December 2008. Articles in the same circle published in the authoritative journals or recently published were included. Among 285 articles, 23 were included in the final analysis.
RESULTS AND CONCLUSION: Understanding of the mechanisms of the bacterial biofilm formation helped us choose a more rational use of antibiotics and effective control over a good clinical infection. After the bacterium biofilm forming, the bacteria biofilm drug resistance increased obviously, but the mechanisms were not yet entirely clear, the action of biofilm ESS physical barrier, special micro-environment, bacterial quorum sensing systems and so on, all played roles in the resistance, they might be multi-factorial synergistic effect. The study of mechanism provides evidences for clinical medicine and drug discovery.

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