中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (16): 3486-3493.doi: 10.12307/2025.412

• 生物材料综述 biomaterial review • 上一篇    下一篇

MXene基水凝胶在创面修复领域的应用

何  蕊，李重一，王瑞瑶，曾  丹，范代娣   

  1. 西北大学化工学院，陕西省可降解生物医用材料重点实验室，陕西省生物材料与发酵工程技术研究中心，陕西省西安市   710127
  • 收稿日期:2023-12-20 接受日期:2024-03-13 出版日期:2025-06-08 发布日期:2024-09-06
  • 通讯作者: 曾丹，副教授，硕士生导师，西北大学化工学院，陕西省可降解生物医用材料重点实验室，陕西省生物材料与发酵工程技术研究中心，陕西省西安市 710127 范代娣，教授，博士生导师，西北大学化工学院，陕西省可降解生物医用材料重点实验室，陕西省生物材料与发酵工程技术研究中心，陕西省西安市 710127
  • 作者简介:何蕊，女，2003年生，甘肃省天水市人，汉族，主要从事组织工程材料的制备研究。 李重一，女，2000年生，陕西省延安市人，汉族，西北大学在读硕士，主要从事纳米功能材料在创面组织工程领域的应用研究。
  • 基金资助:
    科技部国家重点研发计划项目(2019YFA0905200)，项目负责人：范代娣；国家自然科学基金青年项目(22108226)，项目负责人：曾丹；陕西省自然科学基础研究计划青年项目(2021JQ-439)，项目负责人：曾丹

Application of MXene-based hydrogels in wound repair

He Rui, Li Chongyi, Wang Ruiyao, Zeng Dan, Fan Daidi   

  1. School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Northwest University, Xi’an 710127, Shaanxi Province, China
  • Received:2023-12-20 Accepted:2024-03-13 Online:2025-06-08 Published:2024-09-06
  • Contact: Zeng Dan, Associate professor, Master’s supervisor, School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Northwest University, Xi’an 710127, Shaanxi Province, China Fan Daidi, Professor, Doctoral supervisor, School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Northwest University, Xi’an 710127, Shaanxi Province, China
  • About author:He Rui, School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Northwest University, Xi’an 710127, Shaanxi Province, China Li Chongyi, Master candidate, School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Northwest University, Xi’an 710127, Shaanxi Province, China He Rui and Li Chongyi contributed equally to this article.
  • Supported by:
    National Key Research & Development Program of China, No. 2019YFA0905200 (to FDD); Youth Program of National Natural Science Foundation of China, No. 22108226 (to ZD); Youth Project of Natural Science Basic Research Program of Shaanxi Province, No. 2021JQ-439 (to ZD)

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摘要：

文题释义：
MXene基水凝胶：MXene是一类具有类石墨烯结构的由过渡金属碳化物、氮化物或者碳氮化物组成的二维纳米材料，由于具有优异的结构、生物相容性和电学性在生物医药的发展中备受关注。水凝胶是一类柔软灵活且具有3D网络结构的高分子聚合物材料。通过交联等方式将MXene材料与其他物质结合制备的水凝胶为MXene基水凝胶。
创面修复：创面是正常皮肤(组织)由于外力、化学物质、外科手术等外界因素或者某处血液供应障碍等内在因素作用下所造成的损害，通常伴随皮肤完整性的破坏以及一定量正常组织的丢失。水凝胶具有吸收渗液、保持创面湿润的独特优势，利用其本身的修复优势并附加抗菌、抗炎等功效进而促进创面的快速修复。

背景：MXene基水凝胶是一类纳米复合的多功能性水凝胶材料，在慢性创面(如糖尿病足、压疮、癌症及外伤性溃疡等)修复领域有广阔的应用前景。
目的：综述MXene基水凝胶的优势及其在创面修复领域的应用和相关作用机制。
方法：检索中国知网、维普、PubMed、Science Direct数据库中收录的文章，文献检索时限为2010年1月至2023年10月，中文检索关键词为“MXene，水凝胶，组织工程应用，创面修复”，英文检索关键词为“MXene，Hydrogel，Wound repair”，最终选取符合标准的70篇文献进行综述。
结果与结论：MXene基水凝胶在创面组织工程应用中具有优异的力学、导电和光热性能及生物相容性和抗菌性等生物学功效，可以与其他有机物质和无机物质相结合，在水凝胶中产生更大的治疗作用。含有MXene的水凝胶可以结合创面监测、药物递送和缓释以及光热治疗等方式应用于皮肤创面。尽管MXene基水凝胶复合材料的设计和制备已经取得一些良好进展，但仍处于基础研究阶段，缺乏临床验证其功效性和安全性，具有很大发展潜力和应用空间。
https://orcid.org/0009-0006-8133-8688 (何蕊)；https://orcid.org/0009-0005-5033-0651 (李重一)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 纳米功能材料, MXene, 水凝胶, 创面修复, 生物相容性, 创面监测, 药物缓释

Abstract: BACKGROUND: MXene-based hydrogel is a kind of nano-composite multifunctional hydrogel material, which has broad application prospects in the field of chronic wound repair, such as diabetic foot, pressure sore, cancer, and traumatic ulcer.
OBJECTIVE: To review the advantages of MXene-based hydrogels and their application and related action mechanism in wound repair.
METHODS: The articles included in CNKI, VIP, PubMed, and Science Direct databases were searched from January 2010 to October 2023. The key words were “MXene, hydrogel, tissue engineering application, wound repair” in Chinese and “MXene, hydrogel, wound repair” in English. Finally, 70 articles that met the criteria were selected for review.
RESUILTS AND CONCLUSION: MXene-based hydrogels have excellent mechanical, electrical, photo-thermal properties, biocompatibility, and antibacterial effects in wound tissue engineering, and can be combined with other organic and inorganic substances to produce greater therapeutic effects in hydrogel. MXene-based hydrogels can be applied to skin wounds in combination with wound monitoring, drug delivery and release, and photothermal therapy. Despite some progresses in the design and preparation of MXene-based hydrogel composites, they are still in the fundamental research stage. There is a lack of clinical validation regarding their effectiveness and safety, but they hold great potential for development and application.

Key words: nano-functional materials, MXene, hydrogel, wound repair, biocompatibility, wound monitoring, sustained drug release

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