中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (2): 293-299.doi: 10.12307/2022.920

• 组织构建综述 tissue construction review • 上一篇    下一篇

核因子κB受体活化因子信号转导机制与破骨细胞的活化

陈  锋1,任国武1,章晓云2,陈跃平2,石儒生1   

  1. 1广西中医药大学,广西壮族自治区南宁市  530000;2广西中医药大学附属瑞康医院骨科,广西壮族自治区南宁市  530011
  • 收稿日期:2021-11-23 接受日期:2021-12-29 出版日期:2023-01-18 发布日期:2022-06-20
  • 通讯作者: 章晓云,副主任中医师,广西中医药大学附属瑞康医院骨科,广西壮族自治区南宁市 530011
  • 作者简介:陈锋,男,1996年生,广西中医药大学在读硕士,主要从事脊柱、骨关节创伤性疾病的防治研究。
  • 基金资助:
    国家自然科学基金项目(81960803,81760796),项目负责人:陈跃平;广西自然科学基金青年基金(2020GXNSFBA159053),项目负责人:章晓云;广西高校青年教师基础能力提升项目(2019KY0352),项目负责人:章晓云;金天格中青年基金项目(项目61),项目负责人:章晓云

Receptor activator of nuclear factor-kappa B ligand signal transduction mechanism and osteoclast activation

Chen Feng1, Ren Guowu1, Zhang Xiaoyun2, Chen Yueping2, Shi Rusheng1   

  1. 1Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China; 2Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • Received:2021-11-23 Accepted:2021-12-29 Online:2023-01-18 Published:2022-06-20
  • Contact: Zhang Xiaoyun, Associate chief physician, Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
  • About author:Chen Feng, Master candidate, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi Zhuang Autonomous Region, China
  • Supported by:
    the National Natural Science Foundation of China, Nos. 81960803 and 81760796 (both to CYP); Guangxi Natural Science Foundation (Youth Fund), No. 2020GXNSFBA159053 (to ZXY); Guangxi University Young Teachers’ Basic Ability Improvement Project, No. 2019KY0352 (to ZXY); Jin Tiange Young and Middle-aged Fund Project (Project 61) (to ZXY)

摘要:

文题释义:
破骨细胞:破骨细胞是来源于单核巨噬细胞的多核细胞,具有骨吸收的功能,其通过在自身和骨表面之间形成微环境来降解骨骼基质。
核因子κB受体活化因子信号:核因子κB受体活化因子又称肿瘤坏死因子受体超家族成员11a,核因子κB受体活化因子信号与核因子κB受体活化因子配体结合是激活破骨细胞形成的关键信号。

背景:破骨细胞是目前已知的唯一一种骨吸收细胞,其生命活动对骨骼的正常发育和骨骼损伤修复至关重要。在绝大多数骨病中,破骨细胞均显示出异常增殖分化和骨吸收活性增加,而核因子κB受体活化因子信号是调控破骨细胞生命过程的关键信号通路。
目的:总结对破骨细胞核因子κB受体活化因子信号下游靶点及DNA转录因子的最新研究进展,为相关疾病的研究和治疗提供依据。
方法:文献检索数据库包括中国知网、万方、维普数据库、PubMed、Embase及Web of Science数据库,中文检索词为“破骨细胞,破骨前体细胞,骨质疏松症,骨代谢,发病机制,表观遗传学,信号通路,信号传导,转录因子,组织工程”,英文检索词为“osteoclasts,osteoclast precursor cells,osteoporosis,bone metabolism,pathogenesis,epigenetics,signaling pathway,signal transduction,transcription factors,tissue engineering”,时间设置为2017-2021年,根据纳入和排除标准共筛选52篇文献。
结果与结论:核因子κB受体活化因子的特殊结构决定了其信号传导需要与肿瘤坏死因子受体激活因子6结合来募集多种蛋白、活性酶以及细胞因子,形成具有内在酶活性的核因子κB受体活化因子复合物;该复合物通过激活核因子κB、丝裂原活化蛋白激酶等信号通路的传导,最终调控破骨细胞分化、增殖、骨吸收等生命过程。
缩略语:核因子κB受体活化因子:nuclear factor-κb receptor activating factor,RANK;核因子κB受体活化因子配体:receptor activator of NF-κB ligand,RANKL;肿瘤坏死因子受体激活因子:tumor necrosis factor receptor-associated factor,TRAF

https://orcid.org/0000-0001-5979-259X (陈锋)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 破骨细胞, 核因子κB受体活化因子, 细胞信号通路, 骨质疏松症, 骨组织工程, 综述

Abstract: BACKGROUND: Osteoclasts are the only known type of bone resorption cells, and its life activities are essential to the normal development of bones and the repair of bone damage. Osteoclasts show abnormal proliferation and differentiation and increased bone resorption activity in most bone diseases, while receptor activator of nuclear factor-kappa B (RANK) is a key signal pathway that regulates osteoclastogenesis.
OBJECTIVE: To summarize the latest research progress on the downstream targets of osteoclast RANK signal and DNA transcription factors at home and abroad, and provide a basis for the research and treatment of related diseases.
METHODS: A computer-based retrieval was conducted in CNKI, WanFang, VIP, PubMed, Embase and Web of Science databases. The search terms were “osteoclasts, osteoclast precursor cells, osteoporosis, bone metabolism, pathogenesis, epigenetics, signaling pathway, signal transduction, transcription factors, tissue engineering” in Chinese and English. The retrieval time was set to 2017-2021. Finally 52 articles were included according to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: The special structure of RANK determines that its signal transduction needs to be combined with tumor necrosis factor receptor-associated factor 6 to recruit a variety of proteins, active enzymes and cytokines to form a RANK complex with intrinsic enzyme activity. This complex then activates nuclear factor-κB, mitogen-activated protein kinase and other signal pathways, ultimately regulating osteoclast differentiation, proliferation, and bone resorption.

Key words: osteoclast, receptor activator of nuclear factor-kappa B, cell signal pathway, osteoporosis, bone tissue engineering, review

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